{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/102878"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/102878","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Integrating inflammatory stimuli with macromolecules for therapy and sensing of vascular diseases","abstract":"Inflammation is a beneficial component for healing under normal homeostasis. However, excessive inflammation can also aggravate the patient's condition. Biochemical signals elicited under inflammatory conditions are considerably different from those under normal circumstances. Molecules such as pro-inflammatory mediator TNFα and reactive oxygen species are powerful triggers to several signaling mechanisms. In this regard, the overall goal of my research is to integrate inflammatory stimuli TNFα and ROS with macromolecules for therapy and sensing of vascular diseases. To do so, specific features of nanoparticles were studied in Chapter 2 to engineer solutions for the prevailing problems in ischemia and cancer. This thesis presents three approaches in investigating the combination of these potent inflammatory molecules with nanotechnology: (1) TNF-α-releasing liposomes were tethered on the surface of adipose-derived stem cells to enhance their secretory activities (Chapter 3). (2) Thioether-groups were incorporated into micelle-forming polymers to induce a reactive oxygen species-responsive drug release and swelling effect (Chapter 4). (3) Oxidizable chromophores were adsorbed onto support microparticles to form a hydrogen peroxide-sensing patch (Chapter 5). Overall, the results from these studies contribute to a deeper understanding of how to utilize disease biomolecules in the design of novel diagnostics and therapeutics.","abstract_html":"Inflammation is a beneficial component for healing under normal homeostasis. However, excessive inflammation can also aggravate the patient's condition. Biochemical signals elicited under inflammatory conditions are considerably different from those under normal circumstances. Molecules such as pro-inflammatory mediator TNFα and reactive oxygen species are powerful triggers to several signaling mechanisms. In this regard, the overall goal of my research is to integrate inflammatory stimuli TNFα and ROS with macromolecules for therapy and sensing of vascular diseases. To do so, specific features of nanoparticles were studied in Chapter 2 to engineer solutions for the prevailing problems in ischemia and cancer. This thesis presents three approaches in investigating the combination of these potent inflammatory molecules with nanotechnology: (1) TNF-α-releasing liposomes were tethered on the surface of adipose-derived stem cells to enhance their secretory activities (Chapter 3). (2) Thioether-groups were incorporated into micelle-forming polymers to induce a reactive oxygen species-responsive drug release and swelling effect (Chapter 4). (3) Oxidizable chromophores were adsorbed onto support microparticles to form a hydrogen peroxide-sensing patch (Chapter 5). Overall, the results from these studies contribute to a deeper understanding of how to utilize disease biomolecules in the design of novel diagnostics and therapeutics.","abstract_has_math":false,"creators":["Leong Jiayu, Eunice"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemical Engineering","degree_department":null,"school":null,"contributors":["Kong, Hyunjoon","Yang, Yi Yan","Schroeder, Charles","Boppart, Marni"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-02-08T18:39:36Z","date_published":"2019-02-08T18:39:36Z","updated_at":"2026-07-22T22:24:42Z","subjects":["Hydrogen peroxide","nanoparticles"],"languages":["en"],"rights":["Copyright 2018 Eunice Leong Jiayu"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/102878","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kong, Hyunjoon","Yang, Yi Yan","Schroeder, Charles","Boppart, Marni"]},{"key":"dc:creator","label":"Author","values":["Leong Jiayu, Eunice"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-02-08T18:39:36Z","2021-02-09T10:15:45Z","2018-07-27","2018-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Hydrogen peroxide","nanoparticles"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2018 Eunice Leong Jiayu"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/102878"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Inflammation is a beneficial component for healing under normal homeostasis. However, excessive inflammation can also aggravate the patient's condition. Biochemical signals elicited under inflammatory conditions are considerably different from those under normal circumstances. Molecules such as pro-inflammatory mediator TNFα and reactive oxygen species are powerful triggers to several signaling mechanisms. In this regard, the overall goal of my research is to integrate inflammatory stimuli TNFα and ROS with macromolecules for therapy and sensing of vascular diseases. To do so, specific features of nanoparticles were studied in Chapter 2 to engineer solutions for the prevailing problems in ischemia and cancer. This thesis presents three approaches in investigating the combination of these potent inflammatory molecules with nanotechnology: (1) TNF-α-releasing liposomes were tethered on the surface of adipose-derived stem cells to enhance their secretory activities (Chapter 3). (2) Thioether-groups were incorporated into micelle-forming polymers to induce a reactive oxygen species-responsive drug release and swelling effect (Chapter 4). (3) Oxidizable chromophores were adsorbed onto support microparticles to form a hydrogen peroxide-sensing patch (Chapter 5). Overall, the results from these studies contribute to a deeper understanding of how to utilize disease biomolecules in the design of novel diagnostics and therapeutics.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01","The student, Eunice Leong Jiayu, accepted the attached license on 2018-07-25 at 23:39.","The student, Eunice Leong Jiayu, submitted this Dissertation for approval on 2018-07-25 at 23:54.","This Dissertation was approved for publication on 2018-07-27 at 13:05.","DSpace SAF Submission Ingestion Package generated from Vireo submission #12960 on 2019-02-08 at 11:37:28","Made available in DSpace on 2019-02-08T18:39:36Z (GMT). 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However, excessive inflammation can also aggravate the patient's condition. Biochemical signals elicited under inflammatory conditions are considerably different from those under normal circumstances. Molecules such as pro-inflammatory mediator TNFα and reactive oxygen species are powerful triggers to several signaling mechanisms. In this regard, the overall goal of my research is to integrate inflammatory stimuli TNFα and ROS with macromolecules for therapy and sensing of vascular diseases. To do so, specific features of nanoparticles were studied in Chapter 2 to engineer solutions for the prevailing problems in ischemia and cancer. This thesis presents three approaches in investigating the combination of these potent inflammatory molecules with nanotechnology: (1) TNF-α-releasing liposomes were tethered on the surface of adipose-derived stem cells to enhance their secretory activities (Chapter 3). (2) Thioether-groups were incorporated into micelle-forming polymers to induce a reactive oxygen species-responsive drug release and swelling effect (Chapter 4). (3) Oxidizable chromophores were adsorbed onto support microparticles to form a hydrogen peroxide-sensing patch (Chapter 5). Overall, the results from these studies contribute to a deeper understanding of how to utilize disease biomolecules in the design of novel diagnostics and therapeutics.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01","The student, Eunice Leong Jiayu, accepted the attached license on 2018-07-25 at 23:39.","The student, Eunice Leong Jiayu, submitted this Dissertation for approval on 2018-07-25 at 23:54.","This Dissertation was approved for publication on 2018-07-27 at 13:05.","DSpace SAF Submission Ingestion Package generated from Vireo submission #12960 on 2019-02-08 at 11:37:28","Made available in DSpace on 2019-02-08T18:39:36Z (GMT). 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