Assessment of SDOH And AL Impact on Breast and Prostate Cancer Mortality

This dissertation examines how Social Determinants of Health (SDOH) become biologically embodied through allostatic load (AL) and influence breast and prostate cancer severity. Using electronic health record data, geocoded neighborhood disadvantage measures, and longitudinal biomarker profiles, I operationalized multi-subsystem AL (cardiovascular, metabolic, immune, neuroendocrine) across multiple pre-diagnosis time points.These findings advance informatics methods for integrating social and physiologic data and highlight chronic stress biology as a potential pathway underlying cancer disparities.

Author dc:creator

• Himanshu Sharma (141539)

• Disparities around Breast and Prostate Cancer Mortality

Statement dc:rights

• In Copyright
• Open Access after 2028-05-01

DOI dc:identifier

https://doi.org/10.25417/uic.32995025.v1

OAI identifier oai:identifier

oai:figshare.com:article/32995025