{"id":{"repo_id":"uic","oai_identifier":"oai:figshare.com:article/32995025"},"canonical_url":"https://search.dev.ndltd.org/etd/uic/oai:figshare.com:article/32995025","repository":{"repo_id":"uic","name":"University of Illinois - Chicago","base_url":"https://api.figshare.com/v2/oai"},"display":{"title":"Assessment of SDOH And AL Impact on Breast and Prostate Cancer Mortality","abstract":"This dissertation examines how Social Determinants of Health (SDOH) become biologically embodied through allostatic load (AL) and influence breast and prostate cancer severity. Using electronic health record data, geocoded neighborhood disadvantage measures, and longitudinal biomarker profiles, I operationalized multi-subsystem AL (cardiovascular, metabolic, immune, neuroendocrine) across multiple pre-diagnosis time points.These findings advance informatics methods for integrating social and physiologic data and highlight chronic stress biology as a potential pathway underlying cancer disparities.","abstract_html":"This dissertation examines how Social Determinants of Health (SDOH) become biologically embodied through allostatic load (AL) and influence breast and prostate cancer severity. Using electronic health record data, geocoded neighborhood disadvantage measures, and longitudinal biomarker profiles, I operationalized multi-subsystem AL (cardiovascular, metabolic, immune, neuroendocrine) across multiple pre-diagnosis time points.These findings advance informatics methods for integrating social and physiologic data and highlight chronic stress biology as a potential pathway underlying cancer disparities.","abstract_has_math":false,"creators":["Himanshu Sharma (141539)"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-05-01T00:00:00Z","date_published":"2026-05-01T00:00:00Z","updated_at":"2026-07-27T21:33:47Z","subjects":["Disparities around Breast and Prostate Cancer Mortality"],"languages":[],"rights":["In Copyright","Open Access after 2028-05-01"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://doi.org/10.25417/uic.32995025.v1","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Himanshu Sharma (141539)"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2026-05-01T00:00:00Z"]},{"key":"dc:relation","label":"Dc Relation","values":["https://figshare.com/articles/thesis/Assessment_of_SDOH_And_AL_Impact_on_Breast_and_Prostate_Cancer_Mortality/32995025"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Disparities around Breast and Prostate Cancer Mortality"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright","Open Access after 2028-05-01"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.25417/uic.32995025.v1"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This dissertation examines how Social Determinants of Health (SDOH) become biologically embodied through allostatic load (AL) and influence breast and prostate cancer severity. Using electronic health record data, geocoded neighborhood disadvantage measures, and longitudinal biomarker profiles, I operationalized multi-subsystem AL (cardiovascular, metabolic, immune, neuroendocrine) across multiple pre-diagnosis time points.These findings advance informatics methods for integrating social and physiologic data and highlight chronic stress biology as a potential pathway underlying cancer disparities."]},{"key":"dc:title","label":"Title","values":["Assessment of SDOH And AL Impact on Breast and Prostate Cancer Mortality"]}]}],"canonical_facts":{"dc:creator":["Himanshu Sharma (141539)"],"dc:date":["2026-05-01T00:00:00Z"],"dc:description":["This dissertation examines how Social Determinants of Health (SDOH) become biologically embodied through allostatic load (AL) and influence breast and prostate cancer severity. Using electronic health record data, geocoded neighborhood disadvantage measures, and longitudinal biomarker profiles, I operationalized multi-subsystem AL (cardiovascular, metabolic, immune, neuroendocrine) across multiple pre-diagnosis time points.These findings advance informatics methods for integrating social and physiologic data and highlight chronic stress biology as a potential pathway underlying cancer disparities."],"dc:identifier":["10.25417/uic.32995025.v1"],"dc:relation":["https://figshare.com/articles/thesis/Assessment_of_SDOH_And_AL_Impact_on_Breast_and_Prostate_Cancer_Mortality/32995025"],"dc:rights":["In Copyright","Open Access after 2028-05-01"],"dc:subject":["Disparities around Breast and Prostate Cancer Mortality"],"dc:title":["Assessment of SDOH And AL Impact on Breast and Prostate Cancer Mortality"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T21:33:47Z"}