COMPUTATIONAL MODELLING OF PROTEIN FIBRILLATION WITH APPLICATION TO GLUCAGON

A computational method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method is shown to successfully reproduce a number of experimentally determined fibril structures.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Medicinal Chemistry and Molecular Pharmacology

Year

2015

Author dc:creator

• Tabatabaei Ghomi, Hamed

Contributors dc:contributor

• Markus A Lill
• Elizabeth M Topp
• Carol B Post
• Chiwook Park
• Daisuke Kihara

• Amyloid fibril
• Fibrilation
• Glucogon
• Peptide formulation
• Protein structure
• Statistical potential

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1321

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2537