{"id":{"repo_id":"purdue-thes","oai_identifier":"oai:docs.lib.purdue.edu:open_access_dissertations-2537"},"canonical_url":"https://search.dev.ndltd.org/etd/purdue-thes/oai:docs.lib.purdue.edu:open_access_dissertations-2537","repository":{"repo_id":"purdue-thes","name":"Purdue University","base_url":"https://docs.lib.purdue.edu/do/oai/"},"display":{"title":"COMPUTATIONAL MODELLING OF PROTEIN FIBRILLATION WITH APPLICATION TO GLUCAGON","abstract":"A computational method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method is shown to successfully reproduce a number of experimentally determined fibril structures.","abstract_html":"A computational method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method is shown to successfully reproduce a number of experimentally determined fibril structures.","abstract_has_math":false,"creators":["Tabatabaei Ghomi, Hamed"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Medicinal Chemistry and Molecular Pharmacology","degree_department":null,"school":null,"contributors":["Markus A Lill","Elizabeth M Topp","Carol B Post","Chiwook Park","Daisuke Kihara"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-01-01T08:00:00Z","date_published":"2015-01-01T08:00:00Z","updated_at":"2026-07-24T03:54:38Z","subjects":["Amyloid fibril","Fibrilation","Glucogon","Peptide formulation","Protein structure","Statistical potential"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://docs.lib.purdue.edu/open_access_dissertations/1321","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Markus A Lill","Elizabeth M Topp","Carol B Post","Chiwook Park","Daisuke Kihara"]},{"key":"dc:creator","label":"Author","values":["Tabatabaei Ghomi, Hamed"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Medicinal Chemistry and Molecular Pharmacology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Amyloid fibril","Fibrilation","Glucogon","Peptide formulation","Protein structure","Statistical potential"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://docs.lib.purdue.edu/open_access_dissertations/1321"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A computational method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method is shown to successfully reproduce a number of experimentally determined fibril structures."]},{"key":"dc:title","label":"Title","values":["COMPUTATIONAL MODELLING OF PROTEIN FIBRILLATION WITH APPLICATION TO GLUCAGON"]}]}],"canonical_facts":{"dc:contributor":["Markus A Lill","Elizabeth M Topp","Carol B Post","Chiwook Park","Daisuke Kihara"],"dc:creator":["Tabatabaei Ghomi, Hamed"],"dc:description.abstract":["A computational method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method is shown to successfully reproduce a number of experimentally determined fibril structures."],"dc:identifier":["https://docs.lib.purdue.edu/open_access_dissertations/1321"],"dc:subject":["Amyloid fibril","Fibrilation","Glucogon","Peptide formulation","Protein structure","Statistical potential"],"dc:title":["COMPUTATIONAL MODELLING OF PROTEIN FIBRILLATION WITH APPLICATION TO GLUCAGON"],"thesis:degree_discipline":["Medicinal Chemistry and Molecular Pharmacology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T03:54:38Z"}