DEVELOPMENT OF NOVEL DESIGN AND CONTROL APPROACHES FOR INTEGRATED CRYSTALLIZATION OPERATION AND SYSTEMS

Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to design and control pharmaceutical crystallization processes so that the desired process requirement and product critical quality attributes (CQAs), including process yield, crystal purity, crystal size distribution (CSD), crystal shape and polymorphic form can be obtained. Studies about cooling or antisolvent only batch crystallization of pure APIs have been extensively reported in the literature in the last century. But design and control of more complex and integrated crystallization operation and systems require further development to meet the needs of improved CQAs, simplified process design and automated process control in pharmaceutical manufacturing.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Year

2016

Author dc:creator

• Yang, Yang

Contributors dc:contributor

• Zoltan K Nagy
• Gintaras V Reklaitis
• Michael T Harris
• Christopher L Burcham
• James D Litster

• Batch crystallization
• Continuous crystallization
• Crystal size
• Mixed suspension mixed product removal crystallizer
• Optimal control
• Wet milling

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1234

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2450