{"id":{"repo_id":"purdue-thes","oai_identifier":"oai:docs.lib.purdue.edu:open_access_dissertations-2450"},"canonical_url":"https://search.dev.ndltd.org/etd/purdue-thes/oai:docs.lib.purdue.edu:open_access_dissertations-2450","repository":{"repo_id":"purdue-thes","name":"Purdue University","base_url":"https://docs.lib.purdue.edu/do/oai/"},"display":{"title":"DEVELOPMENT OF NOVEL DESIGN AND CONTROL APPROACHES FOR INTEGRATED CRYSTALLIZATION OPERATION AND SYSTEMS","abstract":"Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to design and control pharmaceutical crystallization processes so that the desired process requirement and product critical quality attributes (CQAs), including process yield, crystal purity, crystal size distribution (CSD), crystal shape and polymorphic form can be obtained. Studies about cooling or antisolvent only batch crystallization of pure APIs have been extensively reported in the literature in the last century. But design and control of more complex and integrated crystallization operation and systems require further development to meet the needs of improved CQAs, simplified process design and automated process control in pharmaceutical manufacturing.","abstract_html":"Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to design and control pharmaceutical crystallization processes so that the desired process requirement and product critical quality attributes (CQAs), including process yield, crystal purity, crystal size distribution (CSD), crystal shape and polymorphic form can be obtained. Studies about cooling or antisolvent only batch crystallization of pure APIs have been extensively reported in the literature in the last century. But design and control of more complex and integrated crystallization operation and systems require further development to meet the needs of improved CQAs, simplified process design and automated process control in pharmaceutical manufacturing.","abstract_has_math":false,"creators":["Yang, Yang"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Chemical Engineering","degree_department":null,"school":null,"contributors":["Zoltan K Nagy","Gintaras V Reklaitis","Michael T Harris","Christopher L Burcham","James D Litster"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-01-01T08:00:00Z","date_published":"2016-01-01T08:00:00Z","updated_at":"2026-07-24T03:54:31Z","subjects":["Batch crystallization","Continuous crystallization","Crystal size","Mixed suspension mixed product removal crystallizer","Optimal control","Wet milling"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://docs.lib.purdue.edu/open_access_dissertations/1234","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Zoltan K Nagy","Gintaras V Reklaitis","Michael T Harris","Christopher L Burcham","James D Litster"]},{"key":"dc:creator","label":"Author","values":["Yang, Yang"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Batch crystallization","Continuous crystallization","Crystal size","Mixed suspension mixed product removal crystallizer","Optimal control","Wet milling"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://docs.lib.purdue.edu/open_access_dissertations/1234"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to design and control pharmaceutical crystallization processes so that the desired process requirement and product critical quality attributes (CQAs), including process yield, crystal purity, crystal size distribution (CSD), crystal shape and polymorphic form can be obtained. Studies about cooling or antisolvent only batch crystallization of pure APIs have been extensively reported in the literature in the last century. But design and control of more complex and integrated crystallization operation and systems require further development to meet the needs of improved CQAs, simplified process design and automated process control in pharmaceutical manufacturing."]},{"key":"dc:title","label":"Title","values":["DEVELOPMENT OF NOVEL DESIGN AND CONTROL APPROACHES FOR INTEGRATED CRYSTALLIZATION OPERATION AND SYSTEMS"]}]}],"canonical_facts":{"dc:contributor":["Zoltan K Nagy","Gintaras V Reklaitis","Michael T Harris","Christopher L Burcham","James D Litster"],"dc:creator":["Yang, Yang"],"dc:description.abstract":["Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to design and control pharmaceutical crystallization processes so that the desired process requirement and product critical quality attributes (CQAs), including process yield, crystal purity, crystal size distribution (CSD), crystal shape and polymorphic form can be obtained. Studies about cooling or antisolvent only batch crystallization of pure APIs have been extensively reported in the literature in the last century. But design and control of more complex and integrated crystallization operation and systems require further development to meet the needs of improved CQAs, simplified process design and automated process control in pharmaceutical manufacturing."],"dc:identifier":["https://docs.lib.purdue.edu/open_access_dissertations/1234"],"dc:subject":["Batch crystallization","Continuous crystallization","Crystal size","Mixed suspension mixed product removal crystallizer","Optimal control","Wet milling"],"dc:title":["DEVELOPMENT OF NOVEL DESIGN AND CONTROL APPROACHES FOR INTEGRATED CRYSTALLIZATION OPERATION AND SYSTEMS"],"thesis:degree_discipline":["Chemical Engineering"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T03:54:31Z"}