NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM

Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy surplus. Another two types of adipocytes can also be found in human: beige and brown adipocytes. In opposite to white adipocytes, beige and brown adipocytes ameliorate obesity by burning lipids for thermogenesis. Thus, an increase in beige/brown adipocyte content in adipose tissue, termed browning would raise energy expenditure and reduce adiposity.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Animal Science

Year

2015

Author dc:creator

• Bi, Pengpeng

Contributors dc:contributor

• Shihuan Kuang
• Paul Collodi
• Ourania Andrisani
• Henry Chang

• adipocytes
• metabolic syndromes
• Notch signaling
• obesity

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1200

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2416