{"id":{"repo_id":"purdue-thes","oai_identifier":"oai:docs.lib.purdue.edu:open_access_dissertations-2416"},"canonical_url":"https://search.dev.ndltd.org/etd/purdue-thes/oai:docs.lib.purdue.edu:open_access_dissertations-2416","repository":{"repo_id":"purdue-thes","name":"Purdue University","base_url":"https://docs.lib.purdue.edu/do/oai/"},"display":{"title":"NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM","abstract":"Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy surplus. Another two types of adipocytes can also be found in human: beige and brown adipocytes. In opposite to white adipocytes, beige and brown adipocytes ameliorate obesity by burning lipids for thermogenesis. Thus, an increase in beige/brown adipocyte content in adipose tissue, termed browning would raise energy expenditure and reduce adiposity.","abstract_html":"Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy surplus. Another two types of adipocytes can also be found in human: beige and brown adipocytes. In opposite to white adipocytes, beige and brown adipocytes ameliorate obesity by burning lipids for thermogenesis. Thus, an increase in beige/brown adipocyte content in adipose tissue, termed browning would raise energy expenditure and reduce adiposity.","abstract_has_math":false,"creators":["Bi, Pengpeng"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Animal Science","degree_department":null,"school":null,"contributors":["Shihuan Kuang","Paul Collodi","Ourania Andrisani","Henry Chang"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-01-01T08:00:00Z","date_published":"2015-01-01T08:00:00Z","updated_at":"2026-07-24T03:54:31Z","subjects":["adipocytes","metabolic syndromes","Notch signaling","obesity"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://docs.lib.purdue.edu/open_access_dissertations/1200","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Shihuan Kuang","Paul Collodi","Ourania Andrisani","Henry Chang"]},{"key":"dc:creator","label":"Author","values":["Bi, Pengpeng"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["adipocytes","metabolic syndromes","Notch signaling","obesity"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://docs.lib.purdue.edu/open_access_dissertations/1200"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy surplus. Another two types of adipocytes can also be found in human: beige and brown adipocytes. In opposite to white adipocytes, beige and brown adipocytes ameliorate obesity by burning lipids for thermogenesis. Thus, an increase in beige/brown adipocyte content in adipose tissue, termed browning would raise energy expenditure and reduce adiposity."]},{"key":"dc:title","label":"Title","values":["NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM"]}]}],"canonical_facts":{"dc:contributor":["Shihuan Kuang","Paul Collodi","Ourania Andrisani","Henry Chang"],"dc:creator":["Bi, Pengpeng"],"dc:description.abstract":["Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy surplus. Another two types of adipocytes can also be found in human: beige and brown adipocytes. In opposite to white adipocytes, beige and brown adipocytes ameliorate obesity by burning lipids for thermogenesis. Thus, an increase in beige/brown adipocyte content in adipose tissue, termed browning would raise energy expenditure and reduce adiposity."],"dc:identifier":["https://docs.lib.purdue.edu/open_access_dissertations/1200"],"dc:subject":["adipocytes","metabolic syndromes","Notch signaling","obesity"],"dc:title":["NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM"],"thesis:degree_discipline":["Animal Science"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T03:54:31Z"}