MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS

Tissue damage caused by diseases and injuries requires regeneration to recover proper tissue function. Traditional treatments using autologous tissue have not yet met the need for tissue regeneration. Tissue engineering has emerged as an alternative strategy for tissue regeneration. It utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work describes production and characterization of protein-engineered microenvironments that provide biochemical and biophysical cues to modulate stem cell differentiation.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Year

2014

Author dc:creator

• Kim, Yeji

Contributors dc:contributor

• Julie C. Liu
• Chongli Yuan
• Doraiswami Ramkrishna
• Alyssa Panitch

• Biomaterials
• Microenvironments
• Recombinant protein
• Stem cell differentiation

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1070

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2286