{"id":{"repo_id":"purdue-thes","oai_identifier":"oai:docs.lib.purdue.edu:open_access_dissertations-2286"},"canonical_url":"https://search.dev.ndltd.org/etd/purdue-thes/oai:docs.lib.purdue.edu:open_access_dissertations-2286","repository":{"repo_id":"purdue-thes","name":"Purdue University","base_url":"https://docs.lib.purdue.edu/do/oai/"},"display":{"title":"MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS","abstract":"Tissue damage caused by diseases and injuries requires regeneration to recover proper tissue function. Traditional treatments using autologous tissue have not yet met the need for tissue regeneration. Tissue engineering has emerged as an alternative strategy for tissue regeneration. It utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work describes production and characterization of protein-engineered microenvironments that provide biochemical and biophysical cues to modulate stem cell differentiation.","abstract_html":"Tissue damage caused by diseases and injuries requires regeneration to recover proper tissue function. Traditional treatments using autologous tissue have not yet met the need for tissue regeneration. Tissue engineering has emerged as an alternative strategy for tissue regeneration. It utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work describes production and characterization of protein-engineered microenvironments that provide biochemical and biophysical cues to modulate stem cell differentiation.","abstract_has_math":false,"creators":["Kim, Yeji"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Chemical Engineering","degree_department":null,"school":null,"contributors":["Julie C. Liu","Chongli Yuan","Doraiswami Ramkrishna","Alyssa Panitch"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-01-01T08:00:00Z","date_published":"2014-01-01T08:00:00Z","updated_at":"2026-07-24T03:54:17Z","subjects":["Biomaterials","Microenvironments","Recombinant protein","Stem cell differentiation"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://docs.lib.purdue.edu/open_access_dissertations/1070","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Julie C. Liu","Chongli Yuan","Doraiswami Ramkrishna","Alyssa Panitch"]},{"key":"dc:creator","label":"Author","values":["Kim, Yeji"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biomaterials","Microenvironments","Recombinant protein","Stem cell differentiation"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://docs.lib.purdue.edu/open_access_dissertations/1070"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Tissue damage caused by diseases and injuries requires regeneration to recover proper tissue function. Traditional treatments using autologous tissue have not yet met the need for tissue regeneration. Tissue engineering has emerged as an alternative strategy for tissue regeneration. It utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work describes production and characterization of protein-engineered microenvironments that provide biochemical and biophysical cues to modulate stem cell differentiation."]},{"key":"dc:title","label":"Title","values":["MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS"]}]}],"canonical_facts":{"dc:contributor":["Julie C. Liu","Chongli Yuan","Doraiswami Ramkrishna","Alyssa Panitch"],"dc:creator":["Kim, Yeji"],"dc:description.abstract":["Tissue damage caused by diseases and injuries requires regeneration to recover proper tissue function. Traditional treatments using autologous tissue have not yet met the need for tissue regeneration. Tissue engineering has emerged as an alternative strategy for tissue regeneration. It utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work describes production and characterization of protein-engineered microenvironments that provide biochemical and biophysical cues to modulate stem cell differentiation."],"dc:identifier":["https://docs.lib.purdue.edu/open_access_dissertations/1070"],"dc:subject":["Biomaterials","Microenvironments","Recombinant protein","Stem cell differentiation"],"dc:title":["MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS"],"thesis:degree_discipline":["Chemical Engineering"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T03:54:17Z"}