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Massachusetts Institute of Technology

High reliability performance in Amgen Engineering

Abstract

dc:description.abstract

Amgen is in the midst of a transformative initiative to become operationally more efficient. For Amgen Engineering, this initiative has prompted a reevaluation of the entire organization and brought to light the need to standardize, define processes, and promote a culture wherein reliable outcomes are both possible and expected. One way to accomplish this is by evaluating and then implementing the concepts of High Reliability Organization (HRO). This thesis focuses on using concepts such as HRO to evaluate the Engineering organization at Amgen and then provide tools, frameworks, and recommendations for driving increased reliability and greater process maturity across Amgen's entire asset lifecycle (Plan, Build/Lease, Operate/Maintain, Reinvest/Dispose). Three main deliverables resulted from this project's reliability efforts. The first deliverable is a set of recommendations and strategies to help the Engineering organization operate as an HRO. The second deliverable is an enhanced process maturity model that implements reliability concepts to drive the maturity of Engineering's business processes. The model better defines criteria for each level of maturity and will be used as a guidance tool for organizational advancement in the coming years. The last deliverable focuses on the maintain portion of the asset lifecycle, and is a Maintenance Excellence Roadmap that defines what maintenance excellence looks like and provides a strategy to best utilize the systems and tools that Amgen has in place, and will need in the future, to get there.

Degree

thesis:*
Department dc:contributor.department
Leaders for Global Operations Program at MIT
Grantor dc:publisher
Massachusetts Institute of Technology
Year dc:date.issued
2012

Author and committee

dc:creator, dc:contributor.*
Author dc:creator
  • Bolgren, Daniel (Daniel Reade)
Advisor dc:contributor.advisor
  • Robert T. Haslam and Steven Spear.

Subjects

dc:subject × 3

Rights

dc:rights
Statement dc:rights
  • M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
Language dc:language.iso
eng

Identifiers

dc:identifier.*
Handle dc:identifier.uri
http://hdl.handle.net/1721.1/73439
OAI identifier oai:identifier
oai:dspace.mit.edu:1721.1/73439

Chain of custody

source
Harvested from
MIT
Base URL
dspace.mit.edu/oai/request
Last updated
2026-07-22
Source record
OAI-PMH GetRecord
citation

Bolgren, Daniel (Daniel Reade). High reliability performance in Amgen Engineering. Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/73439