Efficiency of background suppression for arterial spin labeling

Arterial spin labeling (ASL), a technique developed for the measurement of local tissue perfusion with MRI, is heavily dependent on distinguishing irrelevant static tissue signal from the labeled blood. Background suppression can greatly reduce motion and other sources of noise in Arterial Spin Labeling MRI. More sophisticated background suppression strategies with many inversion pulses may decrease the ASL signal causing reduced signal-to-noise ratios and quantitative accuracy. Numerical simulations and in-vivo measurements were used to measure the inefficiency of different adiabatic inversion pulses and to optimize pulse selection. The results emphasize the high potential efficiency of adiabatic inversion pulses but also the limited optimal range of pulse parameters.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2005

Author dc:creator

• Garcia, Dairon, 1980-

Advisor dc:contributor.advisor

• David Alsop.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/28688

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/28688