Studies on the total synthesis of gymnocin B

Progress toward the biomimetic total synthesis of gymnocin B is described. Synthesis of the ABCDEFGH fragment has been completed in 30 steps longest linear sequence, using three different types of epoxide-opening cascades and one fragment coupling. Synthesis of the KLMNO fragment has been completed in 27 steps longest linear sequence, using one epoxide-opening cascade and one fragment coupling. The completion plan of gymnocin B is also detailed. [chemical formulas]

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemistry.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2017

Author dc:creator

• Sittihan, Satapanawat

Advisor dc:contributor.advisor

• Timothy F. Jamison.

• Chemistry.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/112442

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/112442