{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/112442"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/112442","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Studies on the total synthesis of gymnocin B","abstract":"Progress toward the biomimetic total synthesis of gymnocin B is described. Synthesis of the ABCDEFGH fragment has been completed in 30 steps longest linear sequence, using three different types of epoxide-opening cascades and one fragment coupling. Synthesis of the KLMNO fragment has been completed in 27 steps longest linear sequence, using one epoxide-opening cascade and one fragment coupling. The completion plan of gymnocin B is also detailed. [chemical formulas]","abstract_html":"Progress toward the biomimetic total synthesis of gymnocin B is described. 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