The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth

<p>Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive incorporation of C¹⁴-labeled choline and ethanolamine into PC and PE, respectively, were done. In general, there was a decrease in the saturated fatty acid composition and an increase in the quantity of unsaturated fatty acids for PC and PE. The incorporation of choiine-1, 2 -C¹⁴bromide into PC was decreased and the incorporation of ethanolamine-UL-C¹⁴HCL into PE was increased, thus indicating alterations in PC and PS metabolism due to the presence of the carcinogens* These changes might contribute to a better understanding of cancer membrane properties. In addition, similarities in the observed metabolic changes caused by the seven carcinogens might contribute to a knowledge of the mechanism of chemical carcinogenesis as well as provide a tool (or method) for assay of environmental chemicals for carcinogenic activity. </p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Nutrition

Year

1972

Author dc:creator

• Velkers, Mara D.

Contributors dc:contributor

• James Blankenship
• U. D. Register
• R. Bruce Wilcox
• Raymond O. West
• Allen Strother

• Nutrition
• Carcinogens; Phosphatidylcholines; Phosphatidylethanolamines

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/1223

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-2637