Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive incorporation of C14-labeled choline and ethanolamine into PC and PE, respectively, were done. In general, there was a decrease in the saturated fatty acid composition and an increase in the quantity of unsaturated fatty acids for PC and PE. The incorporation of choiine-1, 2 -C14 bromide into PC was decreased and the incorporation of ethanolamine-UL-C14 HCL into PE was increased, thus indicating alterations in PC and PS metabolism due to the presence of the carcinogens* These changes might contribute to a better understanding of cancer membrane properties. In addition, similarities in the observed metabolic changes caused by the seven carcinogens might contribute to a knowledge of the mechanism of chemical carcinogenesis as well as provide a tool (or method) for assay of environmental chemicals for carcinogenic activity.
","abstract_html":"<p>Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive incorporation of C<sup>14</sup>-labeled choline and ethanolamine into PC and PE, respectively, were done. In general, there was a decrease in the saturated fatty acid composition and an increase in the quantity of unsaturated fatty acids for PC and PE. The incorporation of choiine-1, 2 -C<sup>14 </sup>bromide into PC was decreased and the incorporation of ethanolamine-UL-C<sup>14 </sup>HCL into PE was increased, thus indicating alterations in PC and PS metabolism due to the presence of the carcinogens* These changes might contribute to a better understanding of cancer membrane properties. In addition, similarities in the observed metabolic changes caused by the seven carcinogens might contribute to a knowledge of the mechanism of chemical carcinogenesis as well as provide a tool (or method) for assay of environmental chemicals for carcinogenic activity. </p>","abstract_has_math":false,"creators":["Velkers, Mara D."],"institution":null,"degree_name":"Master of Science (MS)","degree_level":"Thesis","degree_discipline":"Nutrition","degree_department":null,"school":null,"contributors":["James Blankenship","U. D. Register","R. Bruce Wilcox","Raymond O. West","Allen Strother"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1972,"date_issued":"1972-05-01T07:00:00Z","date_published":"1972-05-01T07:00:00Z","updated_at":"2026-07-24T02:54:10Z","subjects":["Nutrition","Carcinogens; Phosphatidylcholines; Phosphatidylethanolamines"],"languages":["English"],"rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsrepository.llu.edu/etd/1223","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["James Blankenship","U. D. Register","R. Bruce Wilcox","Raymond O. West","Allen Strother"]},{"key":"dc:creator","label":"Author","values":["Velkers, Mara D."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutrition"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Nutrition","Carcinogens; Phosphatidylcholines; Phosphatidylethanolamines"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsrepository.llu.edu/etd/1223"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive incorporation of C14-labeled choline and ethanolamine into PC and PE, respectively, were done. In general, there was a decrease in the saturated fatty acid composition and an increase in the quantity of unsaturated fatty acids for PC and PE. The incorporation of choiine-1, 2 -C14 bromide into PC was decreased and the incorporation of ethanolamine-UL-C14 HCL into PE was increased, thus indicating alterations in PC and PS metabolism due to the presence of the carcinogens* These changes might contribute to a better understanding of cancer membrane properties. In addition, similarities in the observed metabolic changes caused by the seven carcinogens might contribute to a knowledge of the mechanism of chemical carcinogenesis as well as provide a tool (or method) for assay of environmental chemicals for carcinogenic activity.
"]},{"key":"dc:title","label":"Title","values":["The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth"]}]}],"canonical_facts":{"dc:contributor":["James Blankenship","U. D. Register","R. Bruce Wilcox","Raymond O. West","Allen Strother"],"dc:creator":["Velkers, Mara D."],"dc:description.abstract":["Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive incorporation of C14-labeled choline and ethanolamine into PC and PE, respectively, were done. In general, there was a decrease in the saturated fatty acid composition and an increase in the quantity of unsaturated fatty acids for PC and PE. The incorporation of choiine-1, 2 -C14 bromide into PC was decreased and the incorporation of ethanolamine-UL-C14 HCL into PE was increased, thus indicating alterations in PC and PS metabolism due to the presence of the carcinogens* These changes might contribute to a better understanding of cancer membrane properties. In addition, similarities in the observed metabolic changes caused by the seven carcinogens might contribute to a knowledge of the mechanism of chemical carcinogenesis as well as provide a tool (or method) for assay of environmental chemicals for carcinogenic activity.
"],"dc:identifier":["https://scholarsrepository.llu.edu/etd/1223"],"dc:language":["English"],"dc:rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"dc:subject":["Nutrition","Carcinogens; Phosphatidylcholines; Phosphatidylethanolamines"],"dc:title":["The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth"],"thesis:degree_discipline":["Nutrition"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T02:54:10Z"}