The Role of the Parotid Salivary Glands in the Regulation of Insulin Secretion

<p>Stress of handling, partial or complete sialoadenectomy, and the administration of parotid hormone (PH), sodium fluoride (NaF), or guanidino-succinic acid (GSA) were examined for effects on fasting plasma glucose and insulin or effects on intravenous glucose tolerance in male Sprague-Dawley rats. Basal glucose and insulin were substantially elevated as a result of the stress of translocation in large animals, but were not altered in small animals. A rise in plasma insulin occured in control animals 20 minutes following anesthesia and the removal of a blood sample by cardiac puncture but not in animals that had been handled twice daily for one week prior to the experiment.</p> <p>Salivary gland removal did not alter basal insulin or glucose or short (10-minute) glucose tolerance (SGT). Results of long (60-minute) glucose tolerance tests (LGTs), however, suggest that parotidectomized animals secrete more insulin in response to a glucose challenge.</p> <p>PH and GSA administration did not alter glucose tolerance or basal glucose and insulin. Sodium fluoride pretreatment did not change basal values or SGT results, but did increase post-stimulus glucose levels in LGTs. Also, the data from LGTs with NaF pretreatment suggest that NaF increases or prolongs the insulin response to glucose infusion.</p>

Name thesis:degree_name

Doctor of Philosophy (Medical Science)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Philosophy

Year

1981

Author dc:creator

• Millard, Kenneth L.

Contributors dc:contributor

• John Leonora
• Kenneth A. Arendt
• Robert W. Teel
• Elwood S. McCluskey

• Animal Experimentation and Research
• Biochemical Phenomena, Metabolism, and Nutrition
• Physiology
• Salivary Glands; Insulin

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/1438

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-2210