Stress of handling, partial or complete sialoadenectomy, and the administration of parotid hormone (PH), sodium fluoride (NaF), or guanidino-succinic acid (GSA) were examined for effects on fasting plasma glucose and insulin or effects on intravenous glucose tolerance in male Sprague-Dawley rats. Basal glucose and insulin were substantially elevated as a result of the stress of translocation in large animals, but were not altered in small animals. A rise in plasma insulin occured in control animals 20 minutes following anesthesia and the removal of a blood sample by cardiac puncture but not in animals that had been handled twice daily for one week prior to the experiment.
Salivary gland removal did not alter basal insulin or glucose or short (10-minute) glucose tolerance (SGT). Results of long (60-minute) glucose tolerance tests (LGTs), however, suggest that parotidectomized animals secrete more insulin in response to a glucose challenge.
PH and GSA administration did not alter glucose tolerance or basal glucose and insulin. Sodium fluoride pretreatment did not change basal values or SGT results, but did increase post-stimulus glucose levels in LGTs. Also, the data from LGTs with NaF pretreatment suggest that NaF increases or prolongs the insulin response to glucose infusion.
","abstract_html":"<p>Stress of handling, partial or complete sialoadenectomy, and the administration of parotid hormone (PH), sodium fluoride (NaF), or guanidino-succinic acid (GSA) were examined for effects on fasting plasma glucose and insulin or effects on intravenous glucose tolerance in male Sprague-Dawley rats. Basal glucose and insulin were substantially elevated as a result of the stress of translocation in large animals, but were not altered in small animals. A rise in plasma insulin occured in control animals 20 minutes following anesthesia and the removal of a blood sample by cardiac puncture but not in animals that had been handled twice daily for one week prior to the experiment.</p> <p>Salivary gland removal did not alter basal insulin or glucose or short (10-minute) glucose tolerance (SGT). Results of long (60-minute) glucose tolerance tests (LGTs), however, suggest that parotidectomized animals secrete more insulin in response to a glucose challenge.</p> <p>PH and GSA administration did not alter glucose tolerance or basal glucose and insulin. Sodium fluoride pretreatment did not change basal values or SGT results, but did increase post-stimulus glucose levels in LGTs. Also, the data from LGTs with NaF pretreatment suggest that NaF increases or prolongs the insulin response to glucose infusion.</p>","abstract_has_math":false,"creators":["Millard, Kenneth L."],"institution":null,"degree_name":"Doctor of Philosophy (Medical Science)","degree_level":"Dissertation","degree_discipline":"Philosophy","degree_department":null,"school":null,"contributors":["John Leonora","Kenneth A. Arendt","Robert W. Teel","Elwood S. McCluskey"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1981,"date_issued":"1981-06-01T07:00:00Z","date_published":"1981-06-01T07:00:00Z","updated_at":"2026-07-24T02:53:44Z","subjects":["Animal Experimentation and Research","Biochemical Phenomena, Metabolism, and Nutrition","Physiology","Salivary Glands; Insulin"],"languages":["English"],"rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsrepository.llu.edu/etd/1438","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["John Leonora","Kenneth A. Arendt","Robert W. Teel","Elwood S. McCluskey"]},{"key":"dc:creator","label":"Author","values":["Millard, Kenneth L."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Philosophy"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (Medical Science)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Animal Experimentation and Research","Biochemical Phenomena, Metabolism, and Nutrition","Physiology","Salivary Glands; Insulin"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsrepository.llu.edu/etd/1438"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Stress of handling, partial or complete sialoadenectomy, and the administration of parotid hormone (PH), sodium fluoride (NaF), or guanidino-succinic acid (GSA) were examined for effects on fasting plasma glucose and insulin or effects on intravenous glucose tolerance in male Sprague-Dawley rats. Basal glucose and insulin were substantially elevated as a result of the stress of translocation in large animals, but were not altered in small animals. A rise in plasma insulin occured in control animals 20 minutes following anesthesia and the removal of a blood sample by cardiac puncture but not in animals that had been handled twice daily for one week prior to the experiment.
Salivary gland removal did not alter basal insulin or glucose or short (10-minute) glucose tolerance (SGT). Results of long (60-minute) glucose tolerance tests (LGTs), however, suggest that parotidectomized animals secrete more insulin in response to a glucose challenge.
PH and GSA administration did not alter glucose tolerance or basal glucose and insulin. Sodium fluoride pretreatment did not change basal values or SGT results, but did increase post-stimulus glucose levels in LGTs. Also, the data from LGTs with NaF pretreatment suggest that NaF increases or prolongs the insulin response to glucose infusion.
"]},{"key":"dc:title","label":"Title","values":["The Role of the Parotid Salivary Glands in the Regulation of Insulin Secretion"]}]}],"canonical_facts":{"dc:contributor":["John Leonora","Kenneth A. Arendt","Robert W. Teel","Elwood S. McCluskey"],"dc:creator":["Millard, Kenneth L."],"dc:description.abstract":["Stress of handling, partial or complete sialoadenectomy, and the administration of parotid hormone (PH), sodium fluoride (NaF), or guanidino-succinic acid (GSA) were examined for effects on fasting plasma glucose and insulin or effects on intravenous glucose tolerance in male Sprague-Dawley rats. Basal glucose and insulin were substantially elevated as a result of the stress of translocation in large animals, but were not altered in small animals. A rise in plasma insulin occured in control animals 20 minutes following anesthesia and the removal of a blood sample by cardiac puncture but not in animals that had been handled twice daily for one week prior to the experiment.
Salivary gland removal did not alter basal insulin or glucose or short (10-minute) glucose tolerance (SGT). Results of long (60-minute) glucose tolerance tests (LGTs), however, suggest that parotidectomized animals secrete more insulin in response to a glucose challenge.
PH and GSA administration did not alter glucose tolerance or basal glucose and insulin. Sodium fluoride pretreatment did not change basal values or SGT results, but did increase post-stimulus glucose levels in LGTs. Also, the data from LGTs with NaF pretreatment suggest that NaF increases or prolongs the insulin response to glucose infusion.
"],"dc:identifier":["https://scholarsrepository.llu.edu/etd/1438"],"dc:language":["English"],"dc:rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"dc:subject":["Animal Experimentation and Research","Biochemical Phenomena, Metabolism, and Nutrition","Physiology","Salivary Glands; Insulin"],"dc:title":["The Role of the Parotid Salivary Glands in the Regulation of Insulin Secretion"],"thesis:degree_discipline":["Philosophy"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (Medical Science)"]},"updated_at":"2026-07-24T02:53:44Z"}