The Effects of Dietary N-3 Polyunsaturated Fat from Plant Versus Marine Sources on Bochemical Markers of Bone Turnover in Healthy Adults

<p><strong>Objective:</strong> To investigate the effects of dietary n-3 polyunsaturated fat from plant versus marine sources on biochemical markers of bone turnover.</p> <p><strong>Design:</strong> Both studies were controlled, single blind, randomized trials using Latin-square crossover designs.</p> <p><strong>Subjects/Methods:</strong>Twenty-five (12 females and 13 males) and 24 (9 females and 15 males) healthy participants completed the Fish-Walnut Study and the Omega-3 Study, respectively. The Fish-Walnut Study included three diets: [1] control, [2] ALA-rich diet (1.5 oz of walnuts/day, 6 times/week), and [3] EPA/DHA-rich diet (8 oz of salmon/week). The Omega-3 Study included four diets: [1] control, [2] ALA-rich diet (42-49 g flaxseed oil/wk; lOg walnuts, 3 times/week), [3] EPA/DHA-rich diet (1.40/5.04 g EPA/DHA from microalgae oil/wk), and [4] combination diet (including both ALA and EPA/DHA diets). After a 1-week run-in phase, participants were randomly assigned to a diet for 4 weeks each for the Fish-Walnut Study and 8 weeks each for the Omega-3 Study. Biochemical markers of bone turnover [c-telopeptide (CTX); procollagen Type I N-terminal propeptide (PINT); and osteocalcin (OC)] were analyzed in serum at the end of each diet period in both studies.</p> <p><strong>Results:</strong>There were no significant changes in serum CTX, P1NP, and OC among the three diets (p > 0.05) in both studies. In the Fish-Walnut Study, there was a significant negative association between P1NP levels and age (p = 0.005). In the Omega-3 Study, there was a significant negative association between age and CTX (p</p> <p><strong>Conclusion:</strong> Our findings suggest that both an ALA-rich diet and an EPA/DHA-rich diet did not alter biochemical markers of bone resorption (CTX) and formation (P1NP and OC) in healthy adults in this study design.</p>

Name thesis:degree_name

Doctor of Public Health (DrPH)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nutrition

Year

2009

Author dc:creator

• Nguyen, Lan

Contributors dc:contributor

• Sujatha Rajaram
• Subburaman Mohan
• Joan Sabate

• Molecular, Genetic, and Biochemical Nutrition
• Diet therapy -- Nutrition; Fatty acids -- Health aspects; Bones -- Metabolism; Nutritional Assessment; Dietary Fats -- metabolism; Fatty Acids, Unsaturated -- therapeutic use; Fatty Acids, Omega 3 -- therapeutic use; Fish Oils -- therapeutic use; Nuts -- therapeutic use; Plants, Edible -- therapeutic use; Bone and Bones -- metabolism; Health -- Adult; Biological Markers; Cross-Sectional Studies.

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/797

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-1967