Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis

The purpose of this thesis was to determine whether previous exercise training via voluntary wheel running (VWR) would improve cold tolerance by protecting against cold-induced reductions in rectal temperature. We hypothesized that this would be associated with an exercise-induced increase in white adipose tissue browning, which would contribute in an additive manner to cold-induced nonshivering thermogenesis. To examine this, male C57BL6 mice remained sedentary or were given free access to a wheel for 12 days. Mice were then kept at room temperature (25oC) or subjected to cold stress (4oC) for a period of 48 hours. The primary findings were two-fold; 1) prior exercise via VWR protects against cold-induced weight loss, through a mechanism involving increases in food intake and 2) prior exercise via VWR protects against cold-induced reductions in rectal temperature, however this is likely not associated with UCP-1-dependent nonshivering thermogenesis. Rather, the capacity for shivering thermogenesis may be enhanced.

Grantor dc:publisher

University of Guelph

Year dc:date.issued

2018

Author dc:creator

• Knuth, Carly Michelle

Advisor dc:contributor.advisor

• Wright, David

• exercise
• cold
• adipose
• thermogenesis
• UCP
• mice
• browning
• glucose

Statement dc:rights

• Attribution-NoDerivs 2.5 Canada

Licence dc:rights.uri

• http://creativecommons.org/licenses/by-nd/2.5/ca/

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10214/14053

OAI record oai:identifier

https://atrium.lib.uoguelph.ca/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Aatrium.lib.uoguelph.ca%3A10214%2F14053