{"id":{"repo_id":"guelph","oai_identifier":"oai:atrium.lib.uoguelph.ca:10214/14053"},"canonical_url":"https://search.dev.ndltd.org/etd/guelph/oai:atrium.lib.uoguelph.ca:10214/14053","repository":{"repo_id":"guelph","name":"University of Guelph","base_url":"https://atrium.lib.uoguelph.ca/server/oai/request"},"display":{"title":"Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis","abstract":"The purpose of this thesis was to determine whether previous exercise training via voluntary wheel running (VWR) would improve cold tolerance by protecting against cold-induced reductions in rectal temperature. We hypothesized that this would be associated with an exercise-induced increase in white adipose tissue browning, which would contribute in an additive manner to cold-induced nonshivering thermogenesis. To examine this, male C57BL6 mice remained sedentary or were given free access to a wheel for 12 days. Mice were then kept at room temperature (25oC) or subjected to cold stress (4oC) for a period of 48 hours. The primary findings were two-fold; 1) prior exercise via VWR protects against cold-induced weight loss, through a mechanism involving increases in food intake and 2) prior exercise via VWR protects against cold-induced reductions in rectal temperature, however this is likely not associated with UCP-1-dependent nonshivering thermogenesis. Rather, the capacity for shivering thermogenesis may be enhanced.","abstract_html":"The purpose of this thesis was to determine whether previous exercise training via voluntary wheel running (VWR) would improve cold tolerance by protecting against cold-induced reductions in rectal temperature. We hypothesized that this would be associated with an exercise-induced increase in white adipose tissue browning, which would contribute in an additive manner to cold-induced nonshivering thermogenesis. To examine this, male C57BL6 mice remained sedentary or were given free access to a wheel for 12 days. Mice were then kept at room temperature (25oC) or subjected to cold stress (4oC) for a period of 48 hours. The primary findings were two-fold; 1) prior exercise via VWR protects against cold-induced weight loss, through a mechanism involving increases in food intake and 2) prior exercise via VWR protects against cold-induced reductions in rectal temperature, however this is likely not associated with UCP-1-dependent nonshivering thermogenesis. Rather, the capacity for shivering thermogenesis may be enhanced.","abstract_has_math":false,"creators":["Knuth, Carly Michelle"],"institution":"University of Guelph","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Wright, David"],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-07-25","date_published":"2018-07-25","updated_at":"2026-08-21T16:45:07Z","subjects":["exercise","cold","adipose","thermogenesis","UCP","mice","browning","glucose"],"languages":["en"],"rights":["Attribution-NoDerivs 2.5 Canada"],"rights_urls":["http://creativecommons.org/licenses/by-nd/2.5/ca/"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10214/14053","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://atrium.lib.uoguelph.ca/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Aatrium.lib.uoguelph.ca%3A10214%2F14053","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Wright, David"]},{"key":"dc:creator","label":"Author","values":["Knuth, Carly Michelle"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-07-25T14:43:30Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-07-25T14:43:30Z"]},{"key":"dc:date.issued","label":"Date","values":["2018-07-25"]},{"key":"dc:publisher","label":"Institution","values":["University of Guelph"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["exercise","cold","adipose","thermogenesis","UCP","mice","browning","glucose"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Attribution-NoDerivs 2.5 Canada"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://creativecommons.org/licenses/by-nd/2.5/ca/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10214/14053"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The purpose of this thesis was to determine whether previous exercise training via voluntary wheel running (VWR) would improve cold tolerance by protecting against cold-induced reductions in rectal temperature. We hypothesized that this would be associated with an exercise-induced increase in white adipose tissue browning, which would contribute in an additive manner to cold-induced nonshivering thermogenesis. To examine this, male C57BL6 mice remained sedentary or were given free access to a wheel for 12 days. Mice were then kept at room temperature (25oC) or subjected to cold stress (4oC) for a period of 48 hours. The primary findings were two-fold; 1) prior exercise via VWR protects against cold-induced weight loss, through a mechanism involving increases in food intake and 2) prior exercise via VWR protects against cold-induced reductions in rectal temperature, however this is likely not associated with UCP-1-dependent nonshivering thermogenesis. Rather, the capacity for shivering thermogenesis may be enhanced."]},{"key":"dc:title","label":"Title","values":["Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis"]}]}],"canonical_facts":{"dc:contributor.advisor":["Wright, David"],"dc:creator":["Knuth, Carly Michelle"],"dc:date.accessioned":["2018-07-25T14:43:30Z"],"dc:date.available":["2018-07-25T14:43:30Z"],"dc:date.issued":["2018-07-25"],"dc:description.abstract":["The purpose of this thesis was to determine whether previous exercise training via voluntary wheel running (VWR) would improve cold tolerance by protecting against cold-induced reductions in rectal temperature. We hypothesized that this would be associated with an exercise-induced increase in white adipose tissue browning, which would contribute in an additive manner to cold-induced nonshivering thermogenesis. To examine this, male C57BL6 mice remained sedentary or were given free access to a wheel for 12 days. Mice were then kept at room temperature (25oC) or subjected to cold stress (4oC) for a period of 48 hours. The primary findings were two-fold; 1) prior exercise via VWR protects against cold-induced weight loss, through a mechanism involving increases in food intake and 2) prior exercise via VWR protects against cold-induced reductions in rectal temperature, however this is likely not associated with UCP-1-dependent nonshivering thermogenesis. Rather, the capacity for shivering thermogenesis may be enhanced."],"dc:identifier.uri":["http://hdl.handle.net/10214/14053"],"dc:language.iso":["en"],"dc:publisher":["University of Guelph"],"dc:rights":["Attribution-NoDerivs 2.5 Canada"],"dc:rights.uri":["http://creativecommons.org/licenses/by-nd/2.5/ca/"],"dc:subject":["exercise","cold","adipose","thermogenesis","UCP","mice","browning","glucose"],"dc:title":["Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis"],"dc:type":["Thesis"]},"updated_at":"2026-08-21T16:45:07Z"}