Μορφομετρική μελέτη της περιοχής οργάνωσης του πυρηνίσκου (ΠΟΠ) στα νεοπλασματικά κύτταρα της Νόσου του Hodgkin

Eighty-nine lymph nodes from 53 cases of Hodgkin’s disease were studied for the evaluation of (NORs), in formalin fixed, paraffin embedded sections. For determination of morphometric profile of NORs, a semiautomatic image analysis system was used. The parameters that studied were number of NORs in Sternberg-Reed and Hodgkin's cells, area shapes and number of NORs in postcapillary venules and in activated lyphocytes. A high number of NORs were found in neoplastic cells of Hodgkin's disease equal or higher than that observed in non-Hodgkin's lymphomas and various types of carcinomas and sarcomas. The higher number was observed in lymphocyte depleted type and the lower in lymphocyte predominant type. Observations concerning the mean number of NORs in postcapillary venules and activated lymphocytes, gave as a compatibility in the results for the different histological types of the disease, as mentioned above. In conclusion, the findings of this study indicate that neoplastic cells in Hodgkin's disease are highly activated. NORs counting may be a reliable index of studying the activation degree and perhaps the biological behaviour in a great variety of histological material.

Grantor dc:publisher

University of Ioannina

Year dc:date

1991

Authors dc:creator

• Karameris, Andreas
• Καραμέρης, Ανδρέας

• Μορφομετρία
• Νόσος Hodgkin
• Περιοχή οργάνωσης πυρινίσκου
• AG-NOR
• Hodgkin's disease
• Morphometry
• Nucleolar organizer regions
• Ιατρική και Επιστήμες Υγείας
• Επιστήμες Υγείας
• Medical and Health Sciences
• Health Sciences

Language dc:language

gre

Identifier

10.12681/eadd/1703

OAI identifier oai:identifier

oai:10442/1703