{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1703"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1703","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Μορφομετρική μελέτη της περιοχής οργάνωσης του πυρηνίσκου (ΠΟΠ) στα νεοπλασματικά κύτταρα της Νόσου του Hodgkin","abstract":"Eighty-nine lymph nodes from 53 cases of Hodgkin’s disease were studied for the evaluation of (NORs), in formalin fixed, paraffin embedded sections. For determination of morphometric profile of NORs, a semiautomatic image analysis system was used. The parameters that studied were number of NORs in Sternberg-Reed and Hodgkin's cells, area shapes and number of NORs in postcapillary venules and in activated lyphocytes. A high number of NORs were found in neoplastic cells of Hodgkin's disease equal or higher than that observed in non-Hodgkin's lymphomas and various types of carcinomas and sarcomas. The higher number was observed in lymphocyte depleted type and the lower in lymphocyte predominant type. Observations concerning the mean number of NORs in postcapillary venules and activated lymphocytes, gave as a compatibility in the results for the different histological types of the disease, as mentioned above. In conclusion, the findings of this study indicate that neoplastic cells in Hodgkin's disease are highly activated. NORs counting may be a reliable index of studying the activation degree and perhaps the biological behaviour in a great variety of histological material.","abstract_html":"Eighty-nine lymph nodes from 53 cases of Hodgkin’s disease were studied for the evaluation of (NORs), in formalin fixed, paraffin embedded sections. For determination of morphometric profile of NORs, a semiautomatic image analysis system was used. The parameters that studied were number of NORs in Sternberg-Reed and Hodgkin's cells, area shapes and number of NORs in postcapillary venules and in activated lyphocytes. A high number of NORs were found in neoplastic cells of Hodgkin's disease equal or higher than that observed in non-Hodgkin's lymphomas and various types of carcinomas and sarcomas. The higher number was observed in lymphocyte depleted type and the lower in lymphocyte predominant type. Observations concerning the mean number of NORs in postcapillary venules and activated lymphocytes, gave as a compatibility in the results for the different histological types of the disease, as mentioned above. In conclusion, the findings of this study indicate that neoplastic cells in Hodgkin's disease are highly activated. NORs counting may be a reliable index of studying the activation degree and perhaps the biological behaviour in a great variety of histological material.","abstract_has_math":false,"creators":["Karameris, Andreas","Καραμέρης, Ανδρέας"],"institution":"University of Ioannina","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1991,"date_issued":"1991","date_published":"1991","updated_at":"2026-07-24T02:25:05Z","subjects":["Μορφομετρία","Νόσος Hodgkin","Περιοχή οργάνωσης πυρινίσκου","AG-NOR","Hodgkin's disease","Morphometry","Nucleolar organizer regions","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Medical and Health Sciences","Health Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1703"],"render_values":[{"text":"10.12681/eadd/1703","href":"https://doi.org/10.12681/eadd/1703","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1703","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Karameris, Andreas","Καραμέρης, Ανδρέας"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1991"]},{"key":"dc:publisher","label":"Institution","values":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Μορφομετρία","Νόσος Hodgkin","Περιοχή οργάνωσης πυρινίσκου","AG-NOR","Hodgkin's disease","Morphometry","Nucleolar organizer regions","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Medical and Health Sciences","Health Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1703","http://hdl.handle.net/10442/hedi/1703"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Eighty-nine lymph nodes from 53 cases of Hodgkin’s disease were studied for the evaluation of (NORs), in formalin fixed, paraffin embedded sections. For determination of morphometric profile of NORs, a semiautomatic image analysis system was used. The parameters that studied were number of NORs in Sternberg-Reed and Hodgkin's cells, area shapes and number of NORs in postcapillary venules and in activated lyphocytes. A high number of NORs were found in neoplastic cells of Hodgkin's disease equal or higher than that observed in non-Hodgkin's lymphomas and various types of carcinomas and sarcomas. The higher number was observed in lymphocyte depleted type and the lower in lymphocyte predominant type. Observations concerning the mean number of NORs in postcapillary venules and activated lymphocytes, gave as a compatibility in the results for the different histological types of the disease, as mentioned above. In conclusion, the findings of this study indicate that neoplastic cells in Hodgkin's disease are highly activated. NORs counting may be a reliable index of studying the activation degree and perhaps the biological behaviour in a great variety of histological material.","Μελετήθηκαν σε τομές παραφίνης με την αργυροφιλική τεχνική εντοπισμού των Περιοχών Οργάνωσης του Πυρηνίσκου (ΠΟΠ), 89 λεμφαδένες από 53 περιπτώσει ς νόσου του Hodgkin. Η μελέτη έγινε με Ημιαυτόματο Μορφομετρικό Σύστημα που περιλαμβάνει Η/Υ, μορφομετρική τράπεζα και το κατάλληλο λογισμικό. Οι παράμετροι που μελετήθηκαν ήταν οι περιεκτικότητες των κυττάρων Sternberg Reed και Hodgkin σε ΠΟΠ, οι μεγαλύτεροι διάμετροι, τα εμβαδά και σχήματα των ΠΟΠ καθώς και η περιεκτικότητα σε ΠΟΠ των μετατριχοειδικών φλεβιδίων και των ενεργοποιημένων λεμφοκυττάρων. Τα αποτελέσματα έδειξαν πολύ υψηλή περιεκτικότητα των νεοπλασματικών κυττάρων σε ΠΟΠ αντίστοιχη ή μεγαλύτερη αυτής των υψηλής κακοήθειας μη Hodgkin λεμφωμάτων, καρκινωμάτων, σαρκωμάτων και ενδοκρινικών νεοπλασμάτων. Η μεγαλύτερη περιεκτικότητα με μεγάλη στατιστική διαφορά από τους υπολοίπους τύπους παρατηρείται στο λεμφοπενικό και η μικρότερη στον λεμφοεπικρατητικό. Αντίστοιχα είναι και τα ευρήματα στα μετατριχοειδικά φλεβίδια και στα ενεργοποιημένα λεμφοκύτταρα. Τα αποτελέσματα οδηγούν στο συμπέρασμα ότι τα νεοπλασματικά κύτταρα της νόσου του Hodgkin είναι σε πολύ υψηλά επίπεδα ενεργοποίησης. Αν ο βαθμός ενεργοποίησης αποδειχθεί ότι αποτελεί και δείκτη βιολογικής συμπεριφοράς τότε η καταμέτρηση των ΠΟΠ αποτελεί μέσο βιολογικής πρόβλεψης."]},{"key":"dc:title","label":"Title","values":["Μορφομετρική μελέτη της περιοχής οργάνωσης του πυρηνίσκου (ΠΟΠ) στα νεοπλασματικά κύτταρα της Νόσου του Hodgkin","Morphometric study of NOR's in neoplastic cells of Hodgkin's disease"]}]}],"canonical_facts":{"dc:creator":["Karameris, Andreas","Καραμέρης, Ανδρέας"],"dc:date":["1991"],"dc:description":["Eighty-nine lymph nodes from 53 cases of Hodgkin’s disease were studied for the evaluation of (NORs), in formalin fixed, paraffin embedded sections. For determination of morphometric profile of NORs, a semiautomatic image analysis system was used. The parameters that studied were number of NORs in Sternberg-Reed and Hodgkin's cells, area shapes and number of NORs in postcapillary venules and in activated lyphocytes. A high number of NORs were found in neoplastic cells of Hodgkin's disease equal or higher than that observed in non-Hodgkin's lymphomas and various types of carcinomas and sarcomas. The higher number was observed in lymphocyte depleted type and the lower in lymphocyte predominant type. Observations concerning the mean number of NORs in postcapillary venules and activated lymphocytes, gave as a compatibility in the results for the different histological types of the disease, as mentioned above. In conclusion, the findings of this study indicate that neoplastic cells in Hodgkin's disease are highly activated. NORs counting may be a reliable index of studying the activation degree and perhaps the biological behaviour in a great variety of histological material.","Μελετήθηκαν σε τομές παραφίνης με την αργυροφιλική τεχνική εντοπισμού των Περιοχών Οργάνωσης του Πυρηνίσκου (ΠΟΠ), 89 λεμφαδένες από 53 περιπτώσει ς νόσου του Hodgkin. Η μελέτη έγινε με Ημιαυτόματο Μορφομετρικό Σύστημα που περιλαμβάνει Η/Υ, μορφομετρική τράπεζα και το κατάλληλο λογισμικό. Οι παράμετροι που μελετήθηκαν ήταν οι περιεκτικότητες των κυττάρων Sternberg Reed και Hodgkin σε ΠΟΠ, οι μεγαλύτεροι διάμετροι, τα εμβαδά και σχήματα των ΠΟΠ καθώς και η περιεκτικότητα σε ΠΟΠ των μετατριχοειδικών φλεβιδίων και των ενεργοποιημένων λεμφοκυττάρων. Τα αποτελέσματα έδειξαν πολύ υψηλή περιεκτικότητα των νεοπλασματικών κυττάρων σε ΠΟΠ αντίστοιχη ή μεγαλύτερη αυτής των υψηλής κακοήθειας μη Hodgkin λεμφωμάτων, καρκινωμάτων, σαρκωμάτων και ενδοκρινικών νεοπλασμάτων. Η μεγαλύτερη περιεκτικότητα με μεγάλη στατιστική διαφορά από τους υπολοίπους τύπους παρατηρείται στο λεμφοπενικό και η μικρότερη στον λεμφοεπικρατητικό. Αντίστοιχα είναι και τα ευρήματα στα μετατριχοειδικά φλεβίδια και στα ενεργοποιημένα λεμφοκύτταρα. Τα αποτελέσματα οδηγούν στο συμπέρασμα ότι τα νεοπλασματικά κύτταρα της νόσου του Hodgkin είναι σε πολύ υψηλά επίπεδα ενεργοποίησης. Αν ο βαθμός ενεργοποίησης αποδειχθεί ότι αποτελεί και δείκτη βιολογικής συμπεριφοράς τότε η καταμέτρηση των ΠΟΠ αποτελεί μέσο βιολογικής πρόβλεψης."],"dc:identifier":["10.12681/eadd/1703","http://hdl.handle.net/10442/hedi/1703"],"dc:language":["gre"],"dc:publisher":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"],"dc:subject":["Μορφομετρία","Νόσος Hodgkin","Περιοχή οργάνωσης πυρινίσκου","AG-NOR","Hodgkin's disease","Morphometry","Nucleolar organizer regions","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Medical and Health Sciences","Health Sciences"],"dc:title":["Μορφομετρική μελέτη της περιοχής οργάνωσης του πυρηνίσκου (ΠΟΠ) στα νεοπλασματικά κύτταρα της Νόσου του Hodgkin","Morphometric study of NOR's in neoplastic cells of Hodgkin's disease"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:05Z"}