National and Kapodistrian University of Athens
Τα κύτταρα Langerhans στο ακανθοκυτταρικό καρκίνωμα του στόματος: ανοσοϊστοχημική μελέτη με την S-100 πρωτεΐνη
Abstract
dc:descriptionIN THE PRESENT STUDY AN EFFORT WAS MADE TO INVESTIGATE ORAL SQUAMUS CELL CARCINOMA FOR THE PRESENCE OF LANGERHANS CELLS (L.C) IN FORMALIN-FIXED, PARAFIN-EMBEDED MATERIAL, BY USING S-100 PROTEIN IN THE INDIRECT IMMUNOPEROXIDASE METHOD. ITWAS FOUND THAT: 1) S-100 PROTEIN IS A GOOD MARKER FOR THE IMMUNOHISTOCHEMICAL IDENTIFICATION OF L.C IN ORAL SQUAMUS CELL CARCINOMA, IN PARAFIN SECTIONS. 2) THE INDIRECT IMMUNOPEROXIDASE METHOD AS WE USED IT IN COMBINATION WITH TRYPSIN, GIVES SATISFACTORY RESULTS FOR THE DEFINITION OF S-100 POSITIVE L.C. 3) A GREATER NUMBER OF L.C IN THE NEOPLASTIC EPITHELIUM OF ORAL SQUAMUS CELL CARCINOMA INCOMPARISON WITH THAT OF THE CONNECTIVE TISSUE ADJACENT TO THE NEOPLASTIC EPITHELIUM AND IN THE NON- NEOPLASTIC EPITHELIUM IS A STATISTICALLY SIGNIFICANT DIFFERENCE. 4) THE NUMBER OF L.C IN THE CONNECTIVE TISSUE, ADJACENT TO THE NEOPLASTIC EPITHELIUM WAS GREATER THAN THAT OF THE LAMINA PROPRIA OF THE NON-NEOPLASTICEPITHELIUM IN A STATISTICALLY SIGNIFICANT DIFFERENCE AS WELL. 5) THERE WAS A POSITIVE RELATIONSHIP BETWEEN THE NUMBER OF L.C AND THE NUMBER OF LYMPHOCYTES INTHE CONNECTIVE TISSUE ADJACENT TO THE NEOPLASTIC EPITHELIUM. THE FINDINGS ARE INDICATIONS OF A LOCAL IMMUNOLOGIC REACTIONS OF THE HOST TOWARDS THE DEVELOPINGTUMOR, WHICH THROUGH THE IMMUNOLOGIC FUNCTIONS OF L.C AND THE LYMPHOCYTES OF ORAL MUCOSA AND PARTICULARLY THROUGH OF L.C FOR PRESENTING ANTIGENS TO T-LYMPHOCYTES.
Degree
thesis:*- Grantor dc:publisher
- National and Kapodistrian University of Athens
- Year dc:date
- 1988
Author and committee
dc:creator, dc:contributor.*- Authors dc:creator
-
- Loumou, Panagiota
- Λούμου, Παναγιώτα
Subjects
dc:subject × 12Rights
- Language dc:language
- gre
Identifiers
dc:identifier.*- Identifier
- 10.12681/eadd/0787
- OAI identifier oai:identifier
- oai:10442/0787