Τα κύτταρα Langerhans στο ακανθοκυτταρικό καρκίνωμα του στόματος: ανοσοϊστοχημική μελέτη με την S-100 πρωτεΐνη
type: CreativeWork
description: IN THE PRESENT STUDY AN EFFORT WAS MADE TO INVESTIGATE ORAL SQUAMUS CELL CARCINOMA FOR THE PRESENCE OF LANGERHANS CELLS (L.C) IN FORMALIN-FIXED, PARAFIN-EMBEDED MATERIAL, BY USING S-100 PROTEIN IN THE INDIRECT IMMUNOPEROXIDASE METHOD. ITWAS FOUND THAT: 1) S-100 PROTEIN IS A GOOD MARKER FOR THE IMMUNOHISTOCHEMICAL IDENTIFICATION OF L.C IN ORAL SQUAMUS CELL CARCINOMA, IN PARAFIN SECTIONS. 2) THE INDIRECT IMMUNOPEROXIDASE METHOD AS WE USED IT IN COMBINATION WITH TRYPSIN, GIVES SATISFACTORY RESULTS FOR THE DEFINITION OF S-100 POSITIVE L.C. 3) A GREATER NUMBER OF L.C IN THE NEOPLASTIC EPITHELIUM OF ORAL SQUAMUS CELL CARCINOMA INCOMPARISON WITH THAT OF THE CONNECTIVE TISSUE ADJACENT TO THE NEOPLASTIC EPITHELIUM AND IN THE NON- NEOPLASTIC EPITHELIUM IS A STATISTICALLY SIGNIFICANT DIFFERENCE. 4) THE NUMBER OF L.C IN THE CONNECTIVE TISSUE, ADJACENT TO THE NEOPLASTIC EPITHELIUM WAS GREATER THAN THAT OF THE LAMINA PROPRIA OF THE NON-NEOPLASTICEPITHELIUM IN A STATISTICALLY SIGNIFICANT DIFFERENCE AS WELL. 5) THERE WAS A POSITIVE RELATIONSHIP BETWEEN THE NUMBER OF L.C AND THE NUMBER OF LYMPHOCYTES INTHE CONNECTIVE TISSUE ADJACENT TO THE NEOPLASTIC EPITHELIUM. THE FINDINGS ARE INDICATIONS OF A LOCAL IMMUNOLOGIC REACTIONS OF THE HOST TOWARDS THE DEVELOPINGTUMOR, WHICH THROUGH THE IMMUNOLOGIC FUNCTIONS OF L.C AND THE LYMPHOCYTES OF ORAL MUCOSA AND PARTICULARLY THROUGH OF L.C FOR PRESENTING ANTIGENS TO T-LYMPHOCYTES.
abstract: IN THE PRESENT STUDY AN EFFORT WAS MADE TO INVESTIGATE ORAL SQUAMUS CELL CARCINOMA FOR THE PRESENCE OF LANGERHANS CELLS (L.C) IN FORMALIN-FIXED, PARAFIN-EMBEDED MATERIAL, BY USING S-100 PROTEIN IN THE INDIRECT IMMUNOPEROXIDASE METHOD. ITWAS FOUND THAT: 1) S-100 PROTEIN IS A GOOD MARKER FOR THE IMMUNOHISTOCHEMICAL IDENTIFICATION OF L.C IN ORAL SQUAMUS CELL CARCINOMA, IN PARAFIN SECTIONS. 2) THE INDIRECT IMMUNOPEROXIDASE METHOD AS WE USED IT IN COMBINATION WITH TRYPSIN, GIVES SATISFACTORY RESULTS FOR THE DEFINITION OF S-100 POSITIVE L.C. 3) A GREATER NUMBER OF L.C IN THE NEOPLASTIC EPITHELIUM OF ORAL SQUAMUS CELL CARCINOMA INCOMPARISON WITH THAT OF THE CONNECTIVE TISSUE ADJACENT TO THE NEOPLASTIC EPITHELIUM AND IN THE NON- NEOPLASTIC EPITHELIUM IS A STATISTICALLY SIGNIFICANT DIFFERENCE. 4) THE NUMBER OF L.C IN THE CONNECTIVE TISSUE, ADJACENT TO THE NEOPLASTIC EPITHELIUM WAS GREATER THAN THAT OF THE LAMINA PROPRIA OF THE NON-NEOPLASTICEPITHELIUM IN A STATISTICALLY SIGNIFICANT DIFFERENCE AS WELL. 5) THERE WAS A POSITIVE RELATIONSHIP BETWEEN THE NUMBER OF L.C AND THE NUMBER OF LYMPHOCYTES INTHE CONNECTIVE TISSUE ADJACENT TO THE NEOPLASTIC EPITHELIUM. THE FINDINGS ARE INDICATIONS OF A LOCAL IMMUNOLOGIC REACTIONS OF THE HOST TOWARDS THE DEVELOPINGTUMOR, WHICH THROUGH THE IMMUNOLOGIC FUNCTIONS OF L.C AND THE LYMPHOCYTES OF ORAL MUCOSA AND PARTICULARLY THROUGH OF L.C FOR PRESENTING ANTIGENS TO T-LYMPHOCYTES.
author: Loumou, Panagiota
author: Λούμου, Παναγιώτα
language: gre
keywords: S-100 πρωτεΐνη, Ακανθοκυτταρικό καρκίνωμα στόματος, Ανοσοϊστοχημική μέθοδος, Κύτταρα Langerhans, Immunohistochemical method, Langerhans cells, Oral squamous cell carcinoma, S-100 protein, Ιατρική και Επιστήμες Υγείας, Κλινική Ιατρική, Medical and Health Sciences, Clinical Medicine
date published: 1988
date modified: 2026-07-24T02:25:27Z
provider: Greek National Archive of PhD Theses
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: National and Kapodistrian University of Athens

PropertyValue
property ID: DOI
value: 10.12681/eadd/0787

PropertyValue
property ID: Handle
value: http://hdl.handle.net/10442/hedi/0787