IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ ΜΕ ΒΑΣΗ ΦΥΣΙΚΟΧΗΜΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΩΝ ΦΑΡΜΑΚΩΝ ΚΑΙ ΤΩΝ ΦΑΡΜΑΚΟΤΕΧΝΙΚΩΝ ΜΟΡΦΩΝ

THREE APPROACHES HAVE BEEN USED, IN ORDER TO ESTIMATE THE ORAL DRUG BIOAVAILABILITY: (A) IN VITRO DISSOLUTION STUDIES IN THREE DIFFERENT SYSTEMS AND IN VIVO BIOAVAILABILITY STUDIES HAVE BEEN PERFORMED. A MONO GENERAL APPROACH FOR IN VITRO-IN VIVO CORRELATIONS OF DISSOLUTION/RELEASE CHARACTERISTICS CONSIDERING DIFFERENT DRUGS AND FORMULATIONS HAS BEEN SUGGESTED. (B) IN VITRO AND IN VIVO MEMBRANE TRANSPORT STUDIES, FOR FIVE DRUGS, HAVE BEEN PERFORMED IN THREE DIFFERENT SYSTEMS. USING THE ESTIMATED RATE PARAMETERS, A NONLINEAR FITTING TO A THEORETICAL EQUATION HAS BEEN ATTEMPTED, IN ORDER TO EVALUATE THE ABILITY OF A SYSTEM TO PREDICT THE EXTENT OF ORAL ABSORPTION. (C) A THEORETICAL APPROACH FOR THE QUANTITATIVE PREDICTION OF THE FRACTION OF DOSE ABSORBED BASED ON PHYSIOLOGICAL VARIABLES AND PHYSICOCHEMICAL CHARACTERISTICS OF DRUGS, HAS BEEN DEVELOPED.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1987

Authors dc:creator

• Symillides, Moira
• Συμιλλίδου, Μοίρα

• IN VITRO-IN VIVO ΣΥΣΧΕΤΙΣΕΙΣ
• Βιοδιαθεσιμότητα
• ΓΑΣΤΡΕΝΤΕΡΙΚΗ ΑΠΟΡΡΟΦΗΣΗ
• Διαλυτοποίηση
• ΔΙΑΠΕΡΑΣΗ ΜΕΜΒΡΑΝΩΝ
• ΕΞΟΜΟΙΩΣΗ ΑΠΟΡΡΟΦΗΣΗΣ
• ΠΟΣΟΤΙΚΕΣ ΠΡΟΒΛΕΨΕΙΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ
• ΣΤΑΤΙΣΤΙΚΕΣ ΡΟΠΕΣ
• ΣΤΟΜΑΤΙΚΗ ΑΠΟΡΡΟΦΗΣΗ
• ABSORPTION SIMULATION
• Bioavailability
• BUCCAL ABSORPTION
• Dissolution
• FRACTION ABSORBED
• GASTROINTESTINAL ABSORPTION
• IN VITRO-IN VIVOCORRELATIONS
• MEMBRANE TRANSPORT
• QUANTITATIVE PREDICTION OF FRACTION ABSORBED
• STATISTICAL MOMENTS
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Medical and Health Sciences
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0731

OAI identifier oai:identifier

oai:10442/0731