{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0731"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0731","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ ΜΕ ΒΑΣΗ ΦΥΣΙΚΟΧΗΜΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΩΝ ΦΑΡΜΑΚΩΝ ΚΑΙ ΤΩΝ ΦΑΡΜΑΚΟΤΕΧΝΙΚΩΝ ΜΟΡΦΩΝ","abstract":"THREE APPROACHES HAVE BEEN USED, IN ORDER TO ESTIMATE THE ORAL DRUG BIOAVAILABILITY: (A) IN VITRO DISSOLUTION STUDIES IN THREE DIFFERENT SYSTEMS AND IN VIVO BIOAVAILABILITY STUDIES HAVE BEEN PERFORMED. A MONO GENERAL APPROACH FOR IN VITRO-IN VIVO CORRELATIONS OF DISSOLUTION/RELEASE CHARACTERISTICS CONSIDERING DIFFERENT DRUGS AND FORMULATIONS HAS BEEN SUGGESTED. (B) IN VITRO AND IN VIVO MEMBRANE TRANSPORT STUDIES, FOR FIVE DRUGS, HAVE BEEN PERFORMED IN THREE DIFFERENT SYSTEMS. USING THE ESTIMATED RATE PARAMETERS, A NONLINEAR FITTING TO A THEORETICAL EQUATION HAS BEEN ATTEMPTED, IN ORDER TO EVALUATE THE ABILITY OF A SYSTEM TO PREDICT THE EXTENT OF ORAL ABSORPTION. (C) A THEORETICAL APPROACH FOR THE QUANTITATIVE PREDICTION OF THE FRACTION OF DOSE ABSORBED BASED ON PHYSIOLOGICAL VARIABLES AND PHYSICOCHEMICAL CHARACTERISTICS OF DRUGS, HAS BEEN DEVELOPED.","abstract_html":"THREE APPROACHES HAVE BEEN USED, IN ORDER TO ESTIMATE THE ORAL DRUG BIOAVAILABILITY: (A) IN VITRO DISSOLUTION STUDIES IN THREE DIFFERENT SYSTEMS AND IN VIVO BIOAVAILABILITY STUDIES HAVE BEEN PERFORMED. A MONO GENERAL APPROACH FOR IN VITRO-IN VIVO CORRELATIONS OF DISSOLUTION/RELEASE CHARACTERISTICS CONSIDERING DIFFERENT DRUGS AND FORMULATIONS HAS BEEN SUGGESTED. (B) IN VITRO AND IN VIVO MEMBRANE TRANSPORT STUDIES, FOR FIVE DRUGS, HAVE BEEN PERFORMED IN THREE DIFFERENT SYSTEMS. USING THE ESTIMATED RATE PARAMETERS, A NONLINEAR FITTING TO A THEORETICAL EQUATION HAS BEEN ATTEMPTED, IN ORDER TO EVALUATE THE ABILITY OF A SYSTEM TO PREDICT THE EXTENT OF ORAL ABSORPTION. (C) A THEORETICAL APPROACH FOR THE QUANTITATIVE PREDICTION OF THE FRACTION OF DOSE ABSORBED BASED ON PHYSIOLOGICAL VARIABLES AND PHYSICOCHEMICAL CHARACTERISTICS OF DRUGS, HAS BEEN DEVELOPED.","abstract_has_math":false,"creators":["Symillides, Moira","Συμιλλίδου, Μοίρα"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-24T02:25:27Z","subjects":["IN VITRO-IN VIVO ΣΥΣΧΕΤΙΣΕΙΣ","Βιοδιαθεσιμότητα","ΓΑΣΤΡΕΝΤΕΡΙΚΗ ΑΠΟΡΡΟΦΗΣΗ","Διαλυτοποίηση","ΔΙΑΠΕΡΑΣΗ ΜΕΜΒΡΑΝΩΝ","ΕΞΟΜΟΙΩΣΗ ΑΠΟΡΡΟΦΗΣΗΣ","ΠΟΣΟΤΙΚΕΣ ΠΡΟΒΛΕΨΕΙΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ","ΣΤΑΤΙΣΤΙΚΕΣ ΡΟΠΕΣ","ΣΤΟΜΑΤΙΚΗ ΑΠΟΡΡΟΦΗΣΗ","ABSORPTION SIMULATION","Bioavailability","BUCCAL ABSORPTION","Dissolution","FRACTION ABSORBED","GASTROINTESTINAL ABSORPTION","IN VITRO-IN VIVOCORRELATIONS","MEMBRANE TRANSPORT","QUANTITATIVE PREDICTION OF FRACTION ABSORBED","STATISTICAL MOMENTS","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0731"],"render_values":[{"text":"10.12681/eadd/0731","href":"https://doi.org/10.12681/eadd/0731","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0731","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Symillides, Moira","Συμιλλίδου, Μοίρα"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1987"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["IN VITRO-IN VIVO ΣΥΣΧΕΤΙΣΕΙΣ","Βιοδιαθεσιμότητα","ΓΑΣΤΡΕΝΤΕΡΙΚΗ ΑΠΟΡΡΟΦΗΣΗ","Διαλυτοποίηση","ΔΙΑΠΕΡΑΣΗ ΜΕΜΒΡΑΝΩΝ","ΕΞΟΜΟΙΩΣΗ ΑΠΟΡΡΟΦΗΣΗΣ","ΠΟΣΟΤΙΚΕΣ ΠΡΟΒΛΕΨΕΙΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ","ΣΤΑΤΙΣΤΙΚΕΣ ΡΟΠΕΣ","ΣΤΟΜΑΤΙΚΗ ΑΠΟΡΡΟΦΗΣΗ","ABSORPTION SIMULATION","Bioavailability","BUCCAL ABSORPTION","Dissolution","FRACTION ABSORBED","GASTROINTESTINAL ABSORPTION","IN VITRO-IN VIVOCORRELATIONS","MEMBRANE TRANSPORT","QUANTITATIVE PREDICTION OF FRACTION ABSORBED","STATISTICAL MOMENTS","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0731","http://hdl.handle.net/10442/hedi/0731"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["THREE APPROACHES HAVE BEEN USED, IN ORDER TO ESTIMATE THE ORAL DRUG BIOAVAILABILITY: (A) IN VITRO DISSOLUTION STUDIES IN THREE DIFFERENT SYSTEMS AND IN VIVO BIOAVAILABILITY STUDIES HAVE BEEN PERFORMED. A MONO GENERAL APPROACH FOR IN VITRO-IN VIVO CORRELATIONS OF DISSOLUTION/RELEASE CHARACTERISTICS CONSIDERING DIFFERENT DRUGS AND FORMULATIONS HAS BEEN SUGGESTED. (B) IN VITRO AND IN VIVO MEMBRANE TRANSPORT STUDIES, FOR FIVE DRUGS, HAVE BEEN PERFORMED IN THREE DIFFERENT SYSTEMS. USING THE ESTIMATED RATE PARAMETERS, A NONLINEAR FITTING TO A THEORETICAL EQUATION HAS BEEN ATTEMPTED, IN ORDER TO EVALUATE THE ABILITY OF A SYSTEM TO PREDICT THE EXTENT OF ORAL ABSORPTION. (C) A THEORETICAL APPROACH FOR THE QUANTITATIVE PREDICTION OF THE FRACTION OF DOSE ABSORBED BASED ON PHYSIOLOGICAL VARIABLES AND PHYSICOCHEMICAL CHARACTERISTICS OF DRUGS, HAS BEEN DEVELOPED.","ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ ΦΑΡΜΑΚΩΝ ΠΟΥ ΧΟΡΗΓΟΥΝΤΑΙ PER OS, ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΤΡΕΙΣ ΠΡΟΣΕΓΓΙΣΕΙΣ: (Α) ΠΡΑΓΜΑΤΟΠΟΙΗΘΗΚΑΝ IN VITRO ΜΕΛΕΤΕΣ ΔΙΑΛΥΤΟΠΟΙΗΣΗΣ ΣΕ ΤΡΙΑ ΣΥΣΤΗΜΑΤΑ ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ. ΕΠΙΧΕΙΡΗΘΗΚΑΝ ΓΕΝΙΚΟΤΕΡΕΣ IN VITRO-IN VIVO ΣΥΣΧΕΤΙΣΕΙΣ ΧΑΡΑΚΤΗΡΙΣΤΙΚΩΝ ΔΙΑΛΥΤΟΠΟΙΗΣΗΣ/ΑΠΟΔΕΣΜΕΥΣΗΣ, ΠΟΥ ΕΝΣΩΜΑΤΩΝΟΥΝ ΠΕΡΙΣΣΟΤΕΡΑ ΦΑΡΜΑΚΑ ΚΑΙ ΦΑΡΜΑΚΟΤΕΧΝΙΚΕΣ ΜΟΡΦΕΣ. (Β) ΠΡΑΓΜΑΤΟΠΟΙΗΘΗΚΑΝ IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΔΙΑΠΕΡΑΣΗΣ ΜΕΜΒΡΑΝΩΝ, ΓΙΑ ΠΕΝΤΕ ΦΑΡΜΑΚΑ, ΣΕ ΤΡΙΑ ΔΙΑΦΟΡΕΤΙΚΑ ΣΥΣΤΗΜΑΤΑ. ΕΠΙΧΕΙΡΗΘΗΚΕ ΜΗ ΓΡΑΜΜΙΚΗ ΠΡΟΣΑΡΜΟΓΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΣΕ ΘΕΩΡΗΤΙΚΗ ΣΥΝΑΡΤΗΣΗ ΚΑΙ ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΣΥΣΤΗΜΑΤΩΝ ΟΣΟΝ ΑΦΟΡΑ ΤΗΝ ΠΡΟΒΛΕΨΗ ΤΗΣ ΕΚΤΑΣΗΣ ΤΗΣ ΑΠΟΡΡΟΦΗΣΗΣ. (Γ) ΑΝΑΠΤΥΧΘΗΚΕ ΘΕΩΡΗΤΙΚΗ ΠΡΟΣΕΓΓΙΣΗ ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΟΥ ΚΛΑΣΜΑΤΟΣ ΤΗΣ ΔΟΣΗΣ ΠΟΥ ΑΠΟΡΡΟΦΑΤΑΙ, ΜΕ ΒΑΣΗ ΦΥΣΙΟΛΟΓΙΚΕΣ ΠΑΡΑΜΕΤΡΟΥΣ ΚΑΙ ΦΥΣΙΚΟΧΗΜΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΩΝ ΦΑΡΜΑΚΩΝ."]},{"key":"dc:title","label":"Title","values":["IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ ΜΕ ΒΑΣΗ ΦΥΣΙΚΟΧΗΜΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΩΝ ΦΑΡΜΑΚΩΝ ΚΑΙ ΤΩΝ ΦΑΡΜΑΚΟΤΕΧΝΙΚΩΝ ΜΟΡΦΩΝ","IN VITRO AND IN VIVO STUDIES FOR THE ESTIMATION OF BIOAVAILABILITY BASED ON PHYSICOCHEMICAL CHARACTERISTICS OF DRUGS AND DOSAGE FORMS"]}]}],"canonical_facts":{"dc:creator":["Symillides, Moira","Συμιλλίδου, Μοίρα"],"dc:date":["1987"],"dc:description":["THREE APPROACHES HAVE BEEN USED, IN ORDER TO ESTIMATE THE ORAL DRUG BIOAVAILABILITY: (A) IN VITRO DISSOLUTION STUDIES IN THREE DIFFERENT SYSTEMS AND IN VIVO BIOAVAILABILITY STUDIES HAVE BEEN PERFORMED. A MONO GENERAL APPROACH FOR IN VITRO-IN VIVO CORRELATIONS OF DISSOLUTION/RELEASE CHARACTERISTICS CONSIDERING DIFFERENT DRUGS AND FORMULATIONS HAS BEEN SUGGESTED. (B) IN VITRO AND IN VIVO MEMBRANE TRANSPORT STUDIES, FOR FIVE DRUGS, HAVE BEEN PERFORMED IN THREE DIFFERENT SYSTEMS. USING THE ESTIMATED RATE PARAMETERS, A NONLINEAR FITTING TO A THEORETICAL EQUATION HAS BEEN ATTEMPTED, IN ORDER TO EVALUATE THE ABILITY OF A SYSTEM TO PREDICT THE EXTENT OF ORAL ABSORPTION. (C) A THEORETICAL APPROACH FOR THE QUANTITATIVE PREDICTION OF THE FRACTION OF DOSE ABSORBED BASED ON PHYSIOLOGICAL VARIABLES AND PHYSICOCHEMICAL CHARACTERISTICS OF DRUGS, HAS BEEN DEVELOPED.","ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ ΦΑΡΜΑΚΩΝ ΠΟΥ ΧΟΡΗΓΟΥΝΤΑΙ PER OS, ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΤΡΕΙΣ ΠΡΟΣΕΓΓΙΣΕΙΣ: (Α) ΠΡΑΓΜΑΤΟΠΟΙΗΘΗΚΑΝ IN VITRO ΜΕΛΕΤΕΣ ΔΙΑΛΥΤΟΠΟΙΗΣΗΣ ΣΕ ΤΡΙΑ ΣΥΣΤΗΜΑΤΑ ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ. ΕΠΙΧΕΙΡΗΘΗΚΑΝ ΓΕΝΙΚΟΤΕΡΕΣ IN VITRO-IN VIVO ΣΥΣΧΕΤΙΣΕΙΣ ΧΑΡΑΚΤΗΡΙΣΤΙΚΩΝ ΔΙΑΛΥΤΟΠΟΙΗΣΗΣ/ΑΠΟΔΕΣΜΕΥΣΗΣ, ΠΟΥ ΕΝΣΩΜΑΤΩΝΟΥΝ ΠΕΡΙΣΣΟΤΕΡΑ ΦΑΡΜΑΚΑ ΚΑΙ ΦΑΡΜΑΚΟΤΕΧΝΙΚΕΣ ΜΟΡΦΕΣ. (Β) ΠΡΑΓΜΑΤΟΠΟΙΗΘΗΚΑΝ IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΔΙΑΠΕΡΑΣΗΣ ΜΕΜΒΡΑΝΩΝ, ΓΙΑ ΠΕΝΤΕ ΦΑΡΜΑΚΑ, ΣΕ ΤΡΙΑ ΔΙΑΦΟΡΕΤΙΚΑ ΣΥΣΤΗΜΑΤΑ. ΕΠΙΧΕΙΡΗΘΗΚΕ ΜΗ ΓΡΑΜΜΙΚΗ ΠΡΟΣΑΡΜΟΓΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΣΕ ΘΕΩΡΗΤΙΚΗ ΣΥΝΑΡΤΗΣΗ ΚΑΙ ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΣΥΣΤΗΜΑΤΩΝ ΟΣΟΝ ΑΦΟΡΑ ΤΗΝ ΠΡΟΒΛΕΨΗ ΤΗΣ ΕΚΤΑΣΗΣ ΤΗΣ ΑΠΟΡΡΟΦΗΣΗΣ. (Γ) ΑΝΑΠΤΥΧΘΗΚΕ ΘΕΩΡΗΤΙΚΗ ΠΡΟΣΕΓΓΙΣΗ ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΟΥ ΚΛΑΣΜΑΤΟΣ ΤΗΣ ΔΟΣΗΣ ΠΟΥ ΑΠΟΡΡΟΦΑΤΑΙ, ΜΕ ΒΑΣΗ ΦΥΣΙΟΛΟΓΙΚΕΣ ΠΑΡΑΜΕΤΡΟΥΣ ΚΑΙ ΦΥΣΙΚΟΧΗΜΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΩΝ ΦΑΡΜΑΚΩΝ."],"dc:identifier":["10.12681/eadd/0731","http://hdl.handle.net/10442/hedi/0731"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["IN VITRO-IN VIVO ΣΥΣΧΕΤΙΣΕΙΣ","Βιοδιαθεσιμότητα","ΓΑΣΤΡΕΝΤΕΡΙΚΗ ΑΠΟΡΡΟΦΗΣΗ","Διαλυτοποίηση","ΔΙΑΠΕΡΑΣΗ ΜΕΜΒΡΑΝΩΝ","ΕΞΟΜΟΙΩΣΗ ΑΠΟΡΡΟΦΗΣΗΣ","ΠΟΣΟΤΙΚΕΣ ΠΡΟΒΛΕΨΕΙΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ","ΣΤΑΤΙΣΤΙΚΕΣ ΡΟΠΕΣ","ΣΤΟΜΑΤΙΚΗ ΑΠΟΡΡΟΦΗΣΗ","ABSORPTION SIMULATION","Bioavailability","BUCCAL ABSORPTION","Dissolution","FRACTION ABSORBED","GASTROINTESTINAL ABSORPTION","IN VITRO-IN VIVOCORRELATIONS","MEMBRANE TRANSPORT","QUANTITATIVE PREDICTION OF FRACTION ABSORBED","STATISTICAL MOMENTS","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"dc:title":["IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ ΜΕ ΒΑΣΗ ΦΥΣΙΚΟΧΗΜΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΩΝ ΦΑΡΜΑΚΩΝ ΚΑΙ ΤΩΝ ΦΑΡΜΑΚΟΤΕΧΝΙΚΩΝ ΜΟΡΦΩΝ","IN VITRO AND IN VIVO STUDIES FOR THE ESTIMATION OF BIOAVAILABILITY BASED ON PHYSICOCHEMICAL CHARACTERISTICS OF DRUGS AND DOSAGE FORMS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:27Z"}