A Family-Based Association Study of Conduct Disorder.

<p>Conduct disorder (CD) is a psychiatric syndrome in childhood and adolescence that is one of the most common childhood disorders with continuously increasing prevalence but uncertain pathogenesis. We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data is gathered from Collaborative Study on the Genetics of Alcoholism (COGA) and International Multi-Center ADHD Genetics Project (IMAGE).</p><p>Using COGA data, we identified 20 markers which showed suggestive associations (p<10^-3) with CD. Nine of them are located in known genes. Two genes, <em>ADAM10</em> and <em>CAMK2A</em>, which had been reported associated with Alzheimer's disease (AD), bipolar disorder, and depression, were of more concern. Using IMAGE sample, our results were well replicated.</p><p>This study identified several CD associated genetic variants, especially two novel candidate genes. These findings may serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in CD.</p>

Name thesis:degree_name

MPH (Master of Public Health)

Level thesis:degree_level

Thesis - unrestricted

Discipline thesis:degree_discipline

Public Health

Year dc:date.issued

2010

Author dc:creator

• Jian, Xueqiu

• genes
• family-based design
• genome-wide association study
• conduct disorder
• single nucleotide polymorphisms
• Genetics
• Genetics and Genomics
• Life Sciences

Statement dc:rights

• Copyright by the authors.

Repository record dc:identifier

https://dc.etsu.edu/etd/1697

OAI identifier oai:identifier

oai:dc.etsu.edu:etd-3052