Conduct disorder (CD) is a psychiatric syndrome in childhood and adolescence that is one of the most common childhood disorders with continuously increasing prevalence but uncertain pathogenesis. We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data is gathered from Collaborative Study on the Genetics of Alcoholism (COGA) and International Multi-Center ADHD Genetics Project (IMAGE).
Using COGA data, we identified 20 markers which showed suggestive associations (p<10-3) with CD. Nine of them are located in known genes. Two genes, ADAM10 and CAMK2A, which had been reported associated with Alzheimer's disease (AD), bipolar disorder, and depression, were of more concern. Using IMAGE sample, our results were well replicated.
This study identified several CD associated genetic variants, especially two novel candidate genes. These findings may serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in CD.
","abstract_html":"<p>Conduct disorder (CD) is a psychiatric syndrome in childhood and adolescence that is one of the most common childhood disorders with continuously increasing prevalence but uncertain pathogenesis. We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data is gathered from Collaborative Study on the Genetics of Alcoholism (COGA) and International Multi-Center ADHD Genetics Project (IMAGE).</p><p>Using COGA data, we identified 20 markers which showed suggestive associations (p<10<sup>-3</sup>) with CD. Nine of them are located in known genes. Two genes, <em>ADAM10</em> and <em>CAMK2A</em>, which had been reported associated with Alzheimer's disease (AD), bipolar disorder, and depression, were of more concern. Using IMAGE sample, our results were well replicated.</p><p>This study identified several CD associated genetic variants, especially two novel candidate genes. These findings may serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in CD.</p>","abstract_has_math":false,"creators":["Jian, Xueqiu"],"institution":null,"degree_name":"MPH (Master of Public Health)","degree_level":"Thesis - unrestricted","degree_discipline":"Public Health","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-05-08T07:00:00Z","date_published":"2010-05-08T07:00:00Z","updated_at":"2026-07-24T02:20:42Z","subjects":["genes","family-based design","genome-wide association study","conduct disorder","single nucleotide polymorphisms","Genetics","Genetics and Genomics","Life Sciences"],"languages":[],"rights":["Copyright by the authors."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://dc.etsu.edu/etd/1697","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Jian, Xueqiu"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2010-05-08T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Public Health"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis - unrestricted"]},{"key":"thesis:degree_name","label":"Degree Name","values":["MPH (Master of Public Health)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["genes","family-based design","genome-wide association study","conduct disorder","single nucleotide polymorphisms","Genetics","Genetics and Genomics","Life Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["Copyright by the authors."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://dc.etsu.edu/context/etd/article/3052/viewcontent/JianX041710f.pdf","https://dc.etsu.edu/etd/1697"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Conduct disorder (CD) is a psychiatric syndrome in childhood and adolescence that is one of the most common childhood disorders with continuously increasing prevalence but uncertain pathogenesis. We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data is gathered from Collaborative Study on the Genetics of Alcoholism (COGA) and International Multi-Center ADHD Genetics Project (IMAGE).
Using COGA data, we identified 20 markers which showed suggestive associations (p<10-3) with CD. Nine of them are located in known genes. Two genes, ADAM10 and CAMK2A, which had been reported associated with Alzheimer's disease (AD), bipolar disorder, and depression, were of more concern. Using IMAGE sample, our results were well replicated.
This study identified several CD associated genetic variants, especially two novel candidate genes. These findings may serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in CD.
"]},{"key":"dc:title","label":"Title","values":["A Family-Based Association Study of Conduct Disorder."]}]}],"canonical_facts":{"dc:creator":["Jian, Xueqiu"],"dc:date.issued":["2010-05-08T07:00:00Z"],"dc:description.abstract":["Conduct disorder (CD) is a psychiatric syndrome in childhood and adolescence that is one of the most common childhood disorders with continuously increasing prevalence but uncertain pathogenesis. We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data is gathered from Collaborative Study on the Genetics of Alcoholism (COGA) and International Multi-Center ADHD Genetics Project (IMAGE).
Using COGA data, we identified 20 markers which showed suggestive associations (p<10-3) with CD. Nine of them are located in known genes. Two genes, ADAM10 and CAMK2A, which had been reported associated with Alzheimer's disease (AD), bipolar disorder, and depression, were of more concern. Using IMAGE sample, our results were well replicated.
This study identified several CD associated genetic variants, especially two novel candidate genes. These findings may serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in CD.
"],"dc:identifier":["https://dc.etsu.edu/context/etd/article/3052/viewcontent/JianX041710f.pdf","https://dc.etsu.edu/etd/1697"],"dc:rights":["Copyright by the authors."],"dc:subject":["genes","family-based design","genome-wide association study","conduct disorder","single nucleotide polymorphisms","Genetics","Genetics and Genomics","Life Sciences"],"dc:title":["A Family-Based Association Study of Conduct Disorder."],"thesis:degree_discipline":["Public Health"],"thesis:degree_level":["Thesis - unrestricted"],"thesis:degree_name":["MPH (Master of Public Health)"]},"updated_at":"2026-07-24T02:20:42Z"}