Ethno-Racial Background and Risk for Parkinson’s Disease

Parkinson’s disease is the second-most common progressive neurodegenerative disorder in the world. Presently, there is a lack of evidence from large-scale multifactorial studies suggesting a definitive link between race/ethnicity and PD risk. In our research, we conducted a targeted literature review to evaluate and assess the inclusion of ethno-racial factors in the context of PD risk, diagnosis, and epidemiology, and found that only 21 of 410 (5.1%) reviewed articles accounted for ethno-racial factors as an integral part of analysis. Next, we used the Fox Insight dataset to compare the relationships between PD risk, race and known risk factors. PD diagnosis status and race were related, such that the White group had an increased prevalence of PD, while Asian, and Multiracial groups had a lower prevalence. Further analysis is needed with diverse cohorts and information regarding social factors to investigate the relationship of ethno-racial factors and to make research more equitable.

Name thesis:degree_name

Master of Science (M.Sc.)

Level thesis:degree_level

Master's

Discipline thesis:degree_discipline

Neuroscience

Grantor dc:publisher

Carleton University

Year dc:date.issued

2022

Author dc:creator

• Siddiqi, Sara

Statement dc:rights

• Copyright © 2022 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, distribution to students, research and scholarship. Theses may only be shared by linking to the Carleton University Institutional Repository and no part may be copied without proper attribution to the author; no part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.

Language dc:language.iso

en

DOI

10.22215/etd/2022-16198

OAI identifier oai:identifier

oai:carleton.scholaris.ca:20.500.14718/43044