An investigation of the role of N102 of the GnRH receptor in determining the potency of C-terminally modified agonist analogs

Three GnRH receptors with the mutations N102A, N102D and N102K, which were derived from the human GnRH receptor by site directed mutagenesis, were expressed in COS-1 cells. The effects of these mutations on the potency of seven C-terminally modified GnRH agonist analogs for the stimulation of IP production were determined.

Grantor dc:publisher.institution

Division of Chemical Pathology

Year dc:date.issued

2000

Author dc:creator

• Henshall-Howard, Marie-Paule Alix Emilie

Advisor dc:contributor.advisor

• Davidson, James

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/2692

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/2692