{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/2692"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/2692","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"An investigation of the role of N102 of the GnRH receptor in determining the potency of C-terminally modified agonist analogs","abstract":"Three GnRH receptors with the mutations N102A, N102D and N102K, which were derived from the human GnRH receptor by site directed mutagenesis, were expressed in COS-1 cells. The effects of these mutations on the potency of seven C-terminally modified GnRH agonist analogs for the stimulation of IP production were determined.","abstract_html":"Three GnRH receptors with the mutations N102A, N102D and N102K, which were derived from the human GnRH receptor by site directed mutagenesis, were expressed in COS-1 cells. The effects of these mutations on the potency of seven C-terminally modified GnRH agonist analogs for the stimulation of IP production were determined.","abstract_has_math":false,"creators":["Henshall-Howard, Marie-Paule Alix Emilie"],"institution":"Division of Chemical Pathology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Davidson, James"],"committee_chairs":[],"committee_members":[],"year":2000,"date_issued":"2000","date_published":"2000","updated_at":"2026-07-22T22:23:06Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/2692","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Davidson, James"]},{"key":"dc:creator","label":"Author","values":["Henshall-Howard, Marie-Paule Alix Emilie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-28T08:13:58Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-28T08:13:58Z"]},{"key":"dc:date.issued","label":"Date","values":["2000"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Chemical Pathology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/2692"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography : leaves 84-104."]},{"key":"dc:description.abstract","label":"Abstract","values":["Three GnRH receptors with the mutations N102A, N102D and N102K, which were derived from the human GnRH receptor by site directed mutagenesis, were expressed in COS-1 cells. The effects of these mutations on the potency of seven C-terminally modified GnRH agonist analogs for the stimulation of IP production were determined."]},{"key":"dc:title","label":"Title","values":["An investigation of the role of N102 of the GnRH receptor in determining the potency of C-terminally modified agonist analogs"]}]}],"canonical_facts":{"dc:contributor.advisor":["Davidson, James"],"dc:creator":["Henshall-Howard, Marie-Paule Alix Emilie"],"dc:date.accessioned":["2014-07-28T08:13:58Z"],"dc:date.available":["2014-07-28T08:13:58Z"],"dc:date.issued":["2000"],"dc:description":["Bibliography : leaves 84-104."],"dc:description.abstract":["Three GnRH receptors with the mutations N102A, N102D and N102K, which were derived from the human GnRH receptor by site directed mutagenesis, were expressed in COS-1 cells. The effects of these mutations on the potency of seven C-terminally modified GnRH agonist analogs for the stimulation of IP production were determined."],"dc:identifier.uri":["http://hdl.handle.net/11427/2692"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Chemical Pathology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["An investigation of the role of N102 of the GnRH receptor in determining the potency of C-terminally modified agonist analogs"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:06Z"}