한국인 전신성 홍반성 루푸스에서 Fcγ 수용체 유전자들의 다형성

"국문요약 ················································································· ⅰ 차 례 ················································································· ⅳ 그림차례 ················································································· ⅵ 표 차례 ················································································· ⅶ Ⅰ. 서 론 ·················································································· 1 Ⅱ. 재료 및 방법 ········································································ 5 A. 대상 환자군의 선별과 genomic DNA 준비 ·································· 5 1. 루푸스 환자군과 대조군 ····················································· 5 2. 환자군과 대조군으로부터 채혈 ············································· 5 3. Genomic DNA 추출 ························································ 5 B. 단일염기다형성 탐색 ····························································· 5 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 탐색 ································································· 5 2. Fcg 수용체 ⅡB 유전자의 exon5 와 intorn5 부위에서 다형성의 유전자형 탐색 ············································································· 6 C. 단일염기다형성의 유전자형 결정 ·············································· 7 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4, 그리고 Fcg 수용체 ⅡB 유전자의 exon5와 intorn5 부위에서 다형성의 유전자형 결정 ···· 7 E. 통계분석 ··········································································· 8 Ⅲ. 결 과 ················································································· 9 A. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 확인 ········ 9 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 확인 ··································································· 9 2. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 확인 ································································· 10 3. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 통계분석 ·················································································· 10 B. 다형성의 유전자형 결정 ······················································· 11 1. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 결정 ································································ 11 C. 루푸스 환자군과 정상 대조군의 임상적 특징 ································· 15 D. Fcg 수용체 ⅡB 유전자의 단일염기다형성의 유전자형과 임상적 특징과의 상관관계 ·········································································· 17 Ⅳ. 고 찰 ················································································· 19 Ⅴ. 결 론 ················································································ 22 참고 문헌 ················································································ 23 영문요약 ·················································································· 30 "

Author dc:creator

• 김, 건영

Contributors dc:contributor

• 서, 창희
• 대학원 의생명과학과
• 200824379

• Fcγ 수용체
• 다형성
• 전신성 홍반성 루푸스

Language dc:language

ko

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010922
000000010922

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/2271