{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/2271"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/2271","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"한국인 전신성 홍반성 루푸스에서 Fcγ 수용체 유전자들의 다형성","abstract":"\"국문요약 ················································································· ⅰ 차 례 ················································································· ⅳ 그림차례 ················································································· ⅵ 표 차례 ················································································· ⅶ Ⅰ. 서 론 ·················································································· 1 Ⅱ. 재료 및 방법 ········································································ 5 A. 대상 환자군의 선별과 genomic DNA 준비 ·································· 5 1. 루푸스 환자군과 대조군 ····················································· 5 2. 환자군과 대조군으로부터 채혈 ············································· 5 3. Genomic DNA 추출 ························································ 5 B. 단일염기다형성 탐색 ····························································· 5 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 탐색 ································································· 5 2. Fcg 수용체 ⅡB 유전자의 exon5 와 intorn5 부위에서 다형성의 유전자형 탐색 ············································································· 6 C. 단일염기다형성의 유전자형 결정 ·············································· 7 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4, 그리고 Fcg 수용체 ⅡB 유전자의 exon5와 intorn5 부위에서 다형성의 유전자형 결정 ···· 7 E. 통계분석 ··········································································· 8 Ⅲ. 결 과 ················································································· 9 A. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 확인 ········ 9 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 확인 ··································································· 9 2. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 확인 ································································· 10 3. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 통계분석 ·················································································· 10 B. 다형성의 유전자형 결정 ······················································· 11 1. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 결정 ································································ 11 C. 루푸스 환자군과 정상 대조군의 임상적 특징 ································· 15 D. Fcg 수용체 ⅡB 유전자의 단일염기다형성의 유전자형과 임상적 특징과의 상관관계 ·········································································· 17 Ⅳ. 고 찰 ················································································· 19 Ⅴ. 결 론 ················································································ 22 참고 문헌 ················································································ 23 영문요약 ·················································································· 30 \"","abstract_html":""국문요약 ················································································· ⅰ 차 례 ················································································· ⅳ 그림차례 ················································································· ⅵ 표 차례 ················································································· ⅶ Ⅰ. 서 론 ·················································································· 1 Ⅱ. 재료 및 방법 ········································································ 5 A. 대상 환자군의 선별과 genomic DNA 준비 ·································· 5 1. 루푸스 환자군과 대조군 ····················································· 5 2. 환자군과 대조군으로부터 채혈 ············································· 5 3. Genomic DNA 추출 ························································ 5 B. 단일염기다형성 탐색 ····························································· 5 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 탐색 ································································· 5 2. Fcg 수용체 ⅡB 유전자의 exon5 와 intorn5 부위에서 다형성의 유전자형 탐색 ············································································· 6 C. 단일염기다형성의 유전자형 결정 ·············································· 7 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4, 그리고 Fcg 수용체 ⅡB 유전자의 exon5와 intorn5 부위에서 다형성의 유전자형 결정 ···· 7 E. 통계분석 ··········································································· 8 Ⅲ. 결 과 ················································································· 9 A. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 확인 ········ 9 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 확인 ··································································· 9 2. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 확인 ································································· 10 3. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 통계분석 ·················································································· 10 B. 다형성의 유전자형 결정 ······················································· 11 1. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 결정 ································································ 11 C. 루푸스 환자군과 정상 대조군의 임상적 특징 ································· 15 D. Fcg 수용체 ⅡB 유전자의 단일염기다형성의 유전자형과 임상적 특징과의 상관관계 ·········································································· 17 Ⅳ. 고 찰 ················································································· 19 Ⅴ. 결 론 ················································································ 22 참고 문헌 ················································································ 23 영문요약 ·················································································· 30 "","abstract_has_math":false,"creators":["김, 건영"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["서, 창희","대학원 의생명과학과","200824379"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-04-13T05:38:02Z","date_published":"2011-04-13T05:38:02Z","updated_at":"2026-07-24T00:51:34Z","subjects":["Fcγ 수용체","다형성","전신성 홍반성 루푸스"],"languages":["ko"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010922","000000010922"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010922","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010922","code":true},{"text":"000000010922","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/2271","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["서, 창희","대학원 의생명과학과","200824379","김, 건영"]},{"key":"dc:creator","label":"Author","values":["김, 건영"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-04-13T05:38:02Z","2010"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Fcγ 수용체","다형성","전신성 홍반성 루푸스"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ko"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/2271","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010922","000000010922"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["\"국문요약 ················································································· ⅰ 차 례 ················································································· ⅳ 그림차례 ················································································· ⅵ 표 차례 ················································································· ⅶ Ⅰ. 서 론 ·················································································· 1 Ⅱ. 재료 및 방법 ········································································ 5 A. 대상 환자군의 선별과 genomic DNA 준비 ·································· 5 1. 루푸스 환자군과 대조군 ····················································· 5 2. 환자군과 대조군으로부터 채혈 ············································· 5 3. Genomic DNA 추출 ························································ 5 B. 단일염기다형성 탐색 ····························································· 5 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 탐색 ································································· 5 2. Fcg 수용체 ⅡB 유전자의 exon5 와 intorn5 부위에서 다형성의 유전자형 탐색 ············································································· 6 C. 단일염기다형성의 유전자형 결정 ·············································· 7 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4, 그리고 Fcg 수용체 ⅡB 유전자의 exon5와 intorn5 부위에서 다형성의 유전자형 결정 ···· 7 E. 통계분석 ··········································································· 8 Ⅲ. 결 과 ················································································· 9 A. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 확인 ········ 9 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 확인 ··································································· 9 2. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 확인 ································································· 10 3. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 통계분석 ·················································································· 10 B. 다형성의 유전자형 결정 ······················································· 11 1. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 결정 ································································ 11 C. 루푸스 환자군과 정상 대조군의 임상적 특징 ································· 15 D. Fcg 수용체 ⅡB 유전자의 단일염기다형성의 유전자형과 임상적 특징과의 상관관계 ·········································································· 17 Ⅳ. 고 찰 ················································································· 19 Ⅴ. 결 론 ················································································ 22 참고 문헌 ················································································ 23 영문요약 ·················································································· 30 \"","Master"]},{"key":"dc:title","label":"Title","values":["한국인 전신성 홍반성 루푸스에서 Fcγ 수용체 유전자들의 다형성"]}]}],"canonical_facts":{"dc:contributor":["서, 창희","대학원 의생명과학과","200824379","김, 건영"],"dc:creator":["김, 건영"],"dc:date":["2011-04-13T05:38:02Z","2010"],"dc:description":["\"국문요약 ················································································· ⅰ 차 례 ················································································· ⅳ 그림차례 ················································································· ⅵ 표 차례 ················································································· ⅶ Ⅰ. 서 론 ·················································································· 1 Ⅱ. 재료 및 방법 ········································································ 5 A. 대상 환자군의 선별과 genomic DNA 준비 ·································· 5 1. 루푸스 환자군과 대조군 ····················································· 5 2. 환자군과 대조군으로부터 채혈 ············································· 5 3. Genomic DNA 추출 ························································ 5 B. 단일염기다형성 탐색 ····························································· 5 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 탐색 ································································· 5 2. Fcg 수용체 ⅡB 유전자의 exon5 와 intorn5 부위에서 다형성의 유전자형 탐색 ············································································· 6 C. 단일염기다형성의 유전자형 결정 ·············································· 7 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4, 그리고 Fcg 수용체 ⅡB 유전자의 exon5와 intorn5 부위에서 다형성의 유전자형 결정 ···· 7 E. 통계분석 ··········································································· 8 Ⅲ. 결 과 ················································································· 9 A. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 확인 ········ 9 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 확인 ··································································· 9 2. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 확인 ································································· 10 3. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 통계분석 ·················································································· 10 B. 다형성의 유전자형 결정 ······················································· 11 1. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 결정 ································································ 11 C. 루푸스 환자군과 정상 대조군의 임상적 특징 ································· 15 D. Fcg 수용체 ⅡB 유전자의 단일염기다형성의 유전자형과 임상적 특징과의 상관관계 ·········································································· 17 Ⅳ. 고 찰 ················································································· 19 Ⅴ. 결 론 ················································································ 22 참고 문헌 ················································································ 23 영문요약 ·················································································· 30 \"","Master"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/2271","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010922","000000010922"],"dc:language":["ko"],"dc:subject":["Fcγ 수용체","다형성","전신성 홍반성 루푸스"],"dc:title":["한국인 전신성 홍반성 루푸스에서 Fcγ 수용체 유전자들의 다형성"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:34Z"}