Bestimmung der Lösungsstruktur der dritten Extrazellulärdomäne des Signaltransduktors gp130 mittels mehrdimensionaler heteronuklearer NMR-Spektroskopie

The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokin receptor homology region. The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokin-receptor superfamily predicted to consist of six domains in its extracellular part. The second and the third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type-III like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD-loop.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2000

Author dc:creator

• Kernebeck, Thomas

Contributors dc:contributor

• Grötzinger, Joachim

• info:eu-repo/classification/ddc/540
• Chemie
• Cytokine
• Rezeptor
• Signaltransduktion
• Extrazellulärraum
• Domäne
• Mehrdimensionale NMR-Spektroskopie

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121611%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:59866