Bestimmung der Lösungsstruktur der dritten Extrazellulärdomäne des Signaltransduktors gp130 mittels mehrdimensionaler heteronuklearer NMR-Spektroskopie
The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokin receptor homology region. The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokin-receptor superfamily predicted to consist of six domains in its extracellular part. The second and the third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type-III like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD-loop.
info:eu-repo/classification/ddc/540, Chemie, Cytokine, Rezeptor, Signaltransduktion, Extrazellulärraum, Domäne, Mehrdimensionale NMR-Spektroskopie
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