Studien zur kontrollierten Freisetzung biologisch aktiver Substanzen aus resorbierbaren Nano- und Mikrosphären

The aim of the thesis was the preparation and characterization of resorbable drug delivery systems on the basis of nano- and microspheres, used as sustained release systems and for drug targeting. Using acetylic acid, the peptide hormone insulin and the serin protease thrombin studies were carried out to evaluate the impact of several process parameters of the emulsion-evaporation-method on the sphere morphology and their drug release behaviour. By immobilizing of mannose-6-phosphate entities on the surface of resorbable nanospheres, a drug targeting system for plasmids was developed by receptor-induced endocyosis. Commercially available poly(D,L-lactide) (RESOMER R 208) and poly(D,L-lactide-co-glycolide) 50:50 (RESOMER RG 504) were used as materials, both of which have a history of biomedical applications. The controlled release of bioactive substances in scaffolds for the tissue engineering is of particular interest, in addition to purely therapeutic applications. Growth-factors, in particular, can exert a positive influence on the cell proliferation and differentiation and can be incorporated into such tissue engineering systems. Within the present work, procedures were developed to equip different type of scaffolds with nano and micro spheres.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2004

Author dc:creator

• Pereira Paz, Rui Miguel

Contributors dc:contributor

• Höcker, Hartwig

• info:eu-repo/classification/ddc/540
• Chemie
• Mikrosphären
• Nanosphären
• DDS
• Freisetzung
• w/o/w
• o/w
• PLGA
• PDLLA
• Thrombin
• Insulin
• ASS
• emulsion evaporation method

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121314%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:59535