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By immobilizing of mannose-6-phosphate entities on the surface of resorbable nanospheres, a drug targeting system for plasmids was developed by receptor-induced endocyosis. Commercially available poly(D,L-lactide) (RESOMER R 208) and poly(D,L-lactide-co-glycolide) 50:50 (RESOMER RG 504) were used as materials, both of which have a history of biomedical applications. The controlled release of bioactive substances in scaffolds for the tissue engineering is of particular interest, in addition to purely therapeutic applications. Growth-factors, in particular, can exert a positive influence on the cell proliferation and differentiation and can be incorporated into such tissue engineering systems. 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