Asymmetric synthesis of lignans and of α-heteroaryl)alkylamines employing the SAMP-/RAMP-hydrazone method

This Ph. D. work is divided into two main projects. The first project is focused on the asymmetric synthesis of a very important class of natural products: lignans. Thirteen different lignans in high diastereo- and enantioselectivity have been synthesized. In the second project, a highly efficient asymmetric synthesis of a-(heteroaryl)alkylamines, based on nucleophilic 1,2-addition of heteroarenyllithium species to SAMP-/RAMP-hydrazones, has been developed. Moreover the novel methodology was successfully applied to the synthesis of biologically interesting compounds such as a-aminoacids and b-aminosulfones.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2004

Author dc:creator

• Del Signore, Giuseppe

Contributors dc:contributor

• Enders, Dieter

• info:eu-repo/classification/ddc/540
• Lignane
• Asymmetrische Synthese
• Hydrazon-Methode
• Chemie
• Asymmetric synthesis
• natural products
• Lignans
• chiral amines

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121162%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:59373