Leckage der Papille bei gesunden Probanden und Glaukompatienten mittels Scanning-Laser-Ophthalmoskop-Videofluoreszenzangiographie

The investigation of the optic disc and their changes is probably the most important process parameter with glaucoma and glaucoma-suspicion. By numerous picture giving procedures one strives since the beginnings of the ophthalmology to regard the eye background with glaucoma patients in order to draw from this conclusions on the condition from retina and papilla to. While the autors already mentioned (ASHWORTH, B., ROSEN, E., 1975 and TSUKAHARA, S., 1978) used the normal fluorescein angiography, the fluorescein angiograms for the available work in this study with a Scanning laser ophthalmoskope and with adapted digital bit map memory system were noted. Using digital image analysis in late phases of the scanning laser video fluorescein (SLO; Rodenstock Inst.,Ottobrunn, Germany) angiograms (1-12 min) the fluorescence of the optic nerve head and the surrounding retina ( ratio of leakage) was measured quantitatively. This can be made by special computer programs within a short time. Due to our investigations at the normal and at the pathologically changed eye background the conclusion can be pulled -that glaucomatous papilla-change, like leakage by Na-fluorescein, can be substantially better proven than with a simple investigation or with series photographs with a angiogram interval of some seconds -that the standardisation of the leakage can limited as ratio the late angiogram for the improvement of the interindividual comparability to a closer time interval and -that the different operational sequence of the dye passage our understanding of the in-vivo- pathology and physiology of the papilla in substantial points to enrich and new sources of information open. Since fluorescein cannot leave the capillars with existing blood retina barrier, no or only very small fluorescein leakage within the range of the optic nerve head and the excavation is at healthy pro gangs. The digital evaluation of angiogramsof fluorescein angiography confirms the leakage within the range the papilla with glaucoma patients. The vascular increased leakage of the optic nerve head for fluorescein with glaucoma can be rated as indication of an early capillar damage in the sense of a endothelial dysfunction with increased permeability. The differences, which are better pronounced particularly in time 9-10 min ( phase E) for glaucoma like disc, are with eight measuring windows (40 x 40 pixels and/ or 20 x20 pixels) with angiograms with 20° and/ or 40° image field to the retina to show more clearly than with four measuring windows (150 x 150 pixels and/ or 75 x75 pixels) Due to the available investigation this gate time area is suitable best, in order physiological changes of glaucomatous caused to differentiate. Further investigations must show whether existing therapy concepts this phenomenon can positively affect leakage for the benefit of the patient.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2002

Author dc:creator

• Ali, Abdel Saber

Contributors dc:contributor

• Arend, Kay Oliver

• info:eu-repo/classification/ddc/610
• Medizin

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-119198%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:57130