Toxicology and herb-drug interaction of selected anti-hypertension plants used by lay persons in Northern KwaZulu-Natal (South Africa)
type: CreativeWork
description: A recent (2015) ethnobotanical study which was conducted in northern Maputaland showed that the lay people use medicinal plants singularly, in plant combinations, as well as concurrently with conventional drugs to treat hypertension. Because of the lack of studies validating the safety of South African medicinal plants and the limited interactive studies done between medicinal plants and conventional drugs this study was undertaken. The study was designed to validate the safety of 26 medicinal plants used singularly, in 19 plant combinations as well as when combined with conventional hypertension drugs (13 plants). Five medicinal plants (Citrullus lanatus, Cladostemon kirkii, Hyphaene coriacea and Pyrenacantha kaurabassana and Strychnos madagascariensis) investigated in the current study were evaluated for the first time for any toxicology. Apart from the combination between Aloe marlothii and Hypoxis hemerocallidea, none of the combinations investigated in the current study have been previously tested for any toxicity. Aqueous and organic (1:1 dichloromethane-methanol) extracts were prepared. The toxicity was evaluated using three assays [the brine shrimp lethality assay (BSLA), Ames test and MTT assay (human hepatocarcinoma cell line HepG2/C3A)]. The toxicity interaction of the plant combination was evaluated using the sum of fractional inhibitory concentration (ΣFIC). Herb-drug interaction was performed on the aqueous extracts of the 13 medicinal plants which were recorded to be used concurrently with conventional drugs (adcon napamol, aluminum hydroxide, amlodipine, aspirin, enalapril, pharmapress and ridaq). The three assays applied were the CYP3A4 inhibition assay, the beta-glucuronidase inhibition assay as well as the carboxylesterase inhibition assay. These assays were chosen according to the enzymes involved in the metabolism of the hypertension conventional drugs. The overall toxicity profile of the plant extracts tested in BSLA showed that 17 of the organ…
abstract: A recent (2015) ethnobotanical study which was conducted in northern Maputaland showed that the lay people use medicinal plants singularly, in plant combinations, as well as concurrently with conventional drugs to treat hypertension. Because of the lack of studies validating the safety of South African medicinal plants and the limited interactive studies done between medicinal plants and conventional drugs this study was undertaken. The study was designed to validate the safety of 26 medicinal plants used singularly, in 19 plant combinations as well as when combined with conventional hypertension drugs (13 plants). Five medicinal plants (Citrullus lanatus, Cladostemon kirkii, Hyphaene coriacea and Pyrenacantha kaurabassana and Strychnos madagascariensis) investigated in the current study were evaluated for the first time for any toxicology. Apart from the combination between Aloe marlothii and Hypoxis hemerocallidea, none of the combinations investigated in the current study have been previously tested for any toxicity. Aqueous and organic (1:1 dichloromethane-methanol) extracts were prepared. The toxicity was evaluated using three assays [the brine shrimp lethality assay (BSLA), Ames test and MTT assay (human hepatocarcinoma cell line HepG2/C3A)]. The toxicity interaction of the plant combination was evaluated using the sum of fractional inhibitory concentration (ΣFIC). Herb-drug interaction was performed on the aqueous extracts of the 13 medicinal plants which were recorded to be used concurrently with conventional drugs (adcon napamol, aluminum hydroxide, amlodipine, aspirin, enalapril, pharmapress and ridaq). The three assays applied were the CYP3A4 inhibition assay, the beta-glucuronidase inhibition assay as well as the carboxylesterase inhibition assay. These assays were chosen according to the enzymes involved in the metabolism of the hypertension conventional drugs. The overall toxicity profile of the plant extracts tested in BSLA showed that 17 of the organ…
author: Ramulondi, Mmbulaheni
keywords: medicinal plants --Maputaland --hypertension --South Africa
license: https://devspace.unizulu.ac.za/bitstreams/a03a83a3-776b-4388-a038-272ba11f7147/download
date published: 2017
date modified: 2026-07-24T06:16:58Z
provider: University of Zululand
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Zululand