Effects of intensive phase anti tuberculous therapy on hepatic and hematological parameters in patients at the adult university teaching hospital in Lusaka, Zambia
type: CreativeWork
description: Zambia is a high tuberculosis (TB) burden country. Antituberculous medicines are mainstay of TB management. Several reports of antituberculous drug-related haematological and hepatic adverse effects have been noted in other settings. Adverse events have healthcare cost and morbidity implications. Prevalence and severity of these adverse effects is understudied in patients at the University Teaching Hospitals. The purpose of this study was to identify haematological and hepatic abnormalities and compare parameters before treatment and after completion of intensive phase among the TB patients. Factors associated with abnormalities were also determined. A prospective longitudinal study was undertaken at Chest Clinic. Study patients were followed up for 2 months. Full blood count (FBC) and liver function tests (LFTs) were recorded at base-line and at follow-up. Abnormalities were defined according to the 2017 Division of Acquired Immunodeficiency Syndrome Table for Grading the Severity of Adult and Paediatric Adverse Events. Data were analysed using GraphPad Prism version 8.0.1and SPSS version 22.0 Paired t-test and Wilcoxon matched-pairs signed ranks test were used to compare parameters. Logistic regression was performed to determine factors that were predictive of abnormalities. A p < 0.05 was considered statistically significant. A total of 37 patients were involved in the study. 56.8 percent of patients were male. The mean age of patients was 36.2 years (19 – 57 years) while mean body mass index (BMI) was 21.9 kg/m2. Only 37.8 percent of patients were sputum smear positive at baseline. 56.8 percent of patients had human immunodeficiency virus (HIV) co-infection. 45.9 percent of patients were on antiretroviral therapy (ART). 45.2 percent of patients had grade 1-3 aspartate transaminase (AST) derangements at follow-up compared to 29.7 percent at baseline. 5.4 percent of the patients had grade 1-3 alanine transaminase (ALT) derangements at baseline while 9.7 percent of…
abstract: Zambia is a high tuberculosis (TB) burden country. Antituberculous medicines are mainstay of TB management. Several reports of antituberculous drug-related haematological and hepatic adverse effects have been noted in other settings. Adverse events have healthcare cost and morbidity implications. Prevalence and severity of these adverse effects is understudied in patients at the University Teaching Hospitals. The purpose of this study was to identify haematological and hepatic abnormalities and compare parameters before treatment and after completion of intensive phase among the TB patients. Factors associated with abnormalities were also determined. A prospective longitudinal study was undertaken at Chest Clinic. Study patients were followed up for 2 months. Full blood count (FBC) and liver function tests (LFTs) were recorded at base-line and at follow-up. Abnormalities were defined according to the 2017 Division of Acquired Immunodeficiency Syndrome Table for Grading the Severity of Adult and Paediatric Adverse Events. Data were analysed using GraphPad Prism version 8.0.1and SPSS version 22.0 Paired t-test and Wilcoxon matched-pairs signed ranks test were used to compare parameters. Logistic regression was performed to determine factors that were predictive of abnormalities. A p < 0.05 was considered statistically significant. A total of 37 patients were involved in the study. 56.8 percent of patients were male. The mean age of patients was 36.2 years (19 – 57 years) while mean body mass index (BMI) was 21.9 kg/m2. Only 37.8 percent of patients were sputum smear positive at baseline. 56.8 percent of patients had human immunodeficiency virus (HIV) co-infection. 45.9 percent of patients were on antiretroviral therapy (ART). 45.2 percent of patients had grade 1-3 aspartate transaminase (AST) derangements at follow-up compared to 29.7 percent at baseline. 5.4 percent of the patients had grade 1-3 alanine transaminase (ALT) derangements at baseline while 9.7 percent of…
author: Mwaba, Glorious
language: en
keywords: Antituberculus--Zambia, Hepatitis--Zambia, Hematology--Zambia
date published: 2019
date modified: 2026-07-27T22:06:13Z
provider: University of Zambia
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Zambia