Assessment od Adiponectin and Endothelial Nitric Oxide Synthase levels in Black Zambian patients with Hypertension at the University Teaching Hospital, Lusaka
type: CreativeWork
description: Context - A number of biomarkers are implicated in the pathophysiology of hypertension. Low adiponectin levels have been associated with hypertension and this might be due to its effects on endothelial nitric oxide synthase levels. Aims - In this study we aimed to assess plasma adiponectin and endothelial nitric oxide synthase in patients with hypertension.Methods and Results - An analytical cross-sectional study was undertaken in black Zambians. Plasma adiponectin and endothelial nitric oxide synthase levels were assessed in hypertensive and non-hypertensive participants using ELISA. Our results showed that there was no difference in adiponectin levels between hypertensive and non-hypertensive participants (p=0.291). Our results showed that there was no difference in eNOS levels between hypertensive and non-hypertensive participants (p=0.197). Plasma adiponectin showed no correlation with eNOS in hypertension (r=0.036, p=0.825). Conclusion - The study showed that there was no difference in mean adiponectin concentration and mean eNOS concentration between hypertensive patients and non-hypertensive participants. There was no relationship between adiponectin and eNOS levels on their influence on hypertension.
abstract: Context - A number of biomarkers are implicated in the pathophysiology of hypertension. Low adiponectin levels have been associated with hypertension and this might be due to its effects on endothelial nitric oxide synthase levels. Aims - In this study we aimed to assess plasma adiponectin and endothelial nitric oxide synthase in patients with hypertension.Methods and Results - An analytical cross-sectional study was undertaken in black Zambians. Plasma adiponectin and endothelial nitric oxide synthase levels were assessed in hypertensive and non-hypertensive participants using ELISA. Our results showed that there was no difference in adiponectin levels between hypertensive and non-hypertensive participants (p=0.291). Our results showed that there was no difference in eNOS levels between hypertensive and non-hypertensive participants (p=0.197). Plasma adiponectin showed no correlation with eNOS in hypertension (r=0.036, p=0.825). Conclusion - The study showed that there was no difference in mean adiponectin concentration and mean eNOS concentration between hypertensive patients and non-hypertensive participants. There was no relationship between adiponectin and eNOS levels on their influence on hypertension.
author: Ngwira, Zifa
language: en
keywords: Adiponectin, Endothelial Nitric Oxide Synthase, Hypertesion-Lusaka, Zambia
date published: 2015-11-24
date modified: 2026-07-27T22:06:18Z
provider: University of Zambia
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Zambia