{"id":{"repo_id":"zambia","oai_identifier":"oai:dspace.unza.zm:123456789/1082"},"canonical_url":"https://search.dev.ndltd.org/etd/zambia/oai:dspace.unza.zm:123456789/1082","repository":{"repo_id":"zambia","name":"University of Zambia","base_url":"https://dspace.unza.zm/server/oai/request"},"display":{"title":"A Study of Histopathologic Outcomes of Women With Cryotherapy-Ineligible lesions on Cervicography","abstract":"Objectives To determine the association between high grade cervical intraepithelial neoplasia (CIN 2+) and individual acetowhite cryotherapy-ineligible lesion types, as determined by cervicography.Design: a cross sectional study Setting: Gynecologic Cancer Prevention Unit of the University Teaching Hospital, Zambia.Population: Women referred to the study site for histologic evaluation of cryotherapy-ineligible lesions of the cervix were included in the study.Individual acetowhite lesion types which do not meet criteria for cryotherapy include those that (1)cover more than 75% of the transformation zone, (2) disappear into the endocervical canal, (3) contain abnormal vasculature (mosaicism, punctuations, or atypical blood vessels), and (4) are thick.Main outcome measures: Histologic diagnosis of high grade cervical intraepithelial neoplasia (CIN 2+) for each cryotherapy-ineligible acetowhite lesion type of the cervix.Results: A total of 130 women were enrolled into the study. Women with lesions occupying greater than 75% of the transformation zone had five fold greater odds of CIN 2+ than women with other lesions, OR 4.5 (95% CI 2.19.9), p < 0.001. Women with thick acetowhite lesions were less likely to have CIN 2+, OR 1.1 (95% CI 0.4 3.0), p=0.84. Women with lesions disappearing into the endocervix beyond complete visualization were far less likely to have CIN 2+, OR 0.1 (95% CI 0.040.45), p< 0.001. No association was detected between CIN 2+ and lesions with abnormal vessels. After multivariable adjustment, there remained a significant association between lesions covering greater than 75% of the transformation zone and CIN 2+, OR 2.2 (95% CI 1.43.4). However, other individual cryotherapy-ineligible acetowhite lesion types were no longer associated with CIN 2+. Conclusions: Cryotherapy-ineligible acetowhite lesions occupying greater than 75% of the transformation zone diagnosed on cervicography are associated with histopathologic outcome of high grade cervical intraepithelial neoplasia.","abstract_html":"Objectives To determine the association between high grade cervical intraepithelial neoplasia (CIN 2+) and individual acetowhite cryotherapy-ineligible lesion types, as determined by cervicography.Design: a cross sectional study Setting: Gynecologic Cancer Prevention Unit of the University Teaching Hospital, Zambia.Population: Women referred to the study site for histologic evaluation of cryotherapy-ineligible lesions of the cervix were included in the study.Individual acetowhite lesion types which do not meet criteria for cryotherapy include those that (1)cover more than 75% of the transformation zone, (2) disappear into the endocervical canal, (3) contain abnormal vasculature (mosaicism, punctuations, or atypical blood vessels), and (4) are thick.Main outcome measures: Histologic diagnosis of high grade cervical intraepithelial neoplasia (CIN 2+) for each cryotherapy-ineligible acetowhite lesion type of the cervix.Results: A total of 130 women were enrolled into the study. Women with lesions occupying greater than 75% of the transformation zone had five fold greater odds of CIN 2+ than women with other lesions, OR 4.5 (95% CI 2.19.9), p &lt; 0.001. Women with thick acetowhite lesions were less likely to have CIN 2+, OR 1.1 (95% CI 0.4 3.0), p=0.84. Women with lesions disappearing into the endocervix beyond complete visualization were far less likely to have CIN 2+, OR 0.1 (95% CI 0.040.45), p&lt; 0.001. No association was detected between CIN 2+ and lesions with abnormal vessels. After multivariable adjustment, there remained a significant association between lesions covering greater than 75% of the transformation zone and CIN 2+, OR 2.2 (95% CI 1.43.4). However, other individual cryotherapy-ineligible acetowhite lesion types were no longer associated with CIN 2+. Conclusions: Cryotherapy-ineligible acetowhite lesions occupying greater than 75% of the transformation zone diagnosed on cervicography are associated with histopathologic outcome of high grade cervical intraepithelial neoplasia.","abstract_has_math":false,"creators":["Chisele, Samson"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-02-17","date_published":"2012-02-17","updated_at":"2026-07-27T22:06:13Z","subjects":["Cervical Vertebrae(women)--Radiography","Gynecology","Women--medical examinations"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://dspace.unza.zm/handle/123456789/1082","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Chisele, Samson"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2012-02-17T11:15:56Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2012-02-17T11:15:56Z"]},{"key":"dc:date.issued","label":"Date","values":["2012-02-17"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cervical Vertebrae(women)--Radiography","Gynecology","Women--medical examinations"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://dspace.unza.zm/handle/123456789/1082"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Objectives To determine the association between high grade cervical intraepithelial neoplasia (CIN 2+) and individual acetowhite cryotherapy-ineligible lesion types, as determined by cervicography.Design: a cross sectional study Setting: Gynecologic Cancer Prevention Unit of the University Teaching Hospital, Zambia.Population: Women referred to the study site for histologic evaluation of cryotherapy-ineligible lesions of the cervix were included in the study.Individual acetowhite lesion types which do not meet criteria for cryotherapy include those that (1)cover more than 75% of the transformation zone, (2) disappear into the endocervical canal, (3) contain abnormal vasculature (mosaicism, punctuations, or atypical blood vessels), and (4) are thick.Main outcome measures: Histologic diagnosis of high grade cervical intraepithelial neoplasia (CIN 2+) for each cryotherapy-ineligible acetowhite lesion type of the cervix.Results: A total of 130 women were enrolled into the study. Women with lesions occupying greater than 75% of the transformation zone had five fold greater odds of CIN 2+ than women with other lesions, OR 4.5 (95% CI 2.19.9), p < 0.001. Women with thick acetowhite lesions were less likely to have CIN 2+, OR 1.1 (95% CI 0.4 3.0), p=0.84. Women with lesions disappearing into the endocervix beyond complete visualization were far less likely to have CIN 2+, OR 0.1 (95% CI 0.040.45), p< 0.001. No association was detected between CIN 2+ and lesions with abnormal vessels. After multivariable adjustment, there remained a significant association between lesions covering greater than 75% of the transformation zone and CIN 2+, OR 2.2 (95% CI 1.43.4). However, other individual cryotherapy-ineligible acetowhite lesion types were no longer associated with CIN 2+. Conclusions: Cryotherapy-ineligible acetowhite lesions occupying greater than 75% of the transformation zone diagnosed on cervicography are associated with histopathologic outcome of high grade cervical intraepithelial neoplasia."]},{"key":"dc:title","label":"Title","values":["A Study of Histopathologic Outcomes of Women With Cryotherapy-Ineligible lesions on Cervicography"]}]}],"canonical_facts":{"dc:creator":["Chisele, Samson"],"dc:date.accessioned":["2012-02-17T11:15:56Z"],"dc:date.available":["2012-02-17T11:15:56Z"],"dc:date.issued":["2012-02-17"],"dc:description.abstract":["Objectives To determine the association between high grade cervical intraepithelial neoplasia (CIN 2+) and individual acetowhite cryotherapy-ineligible lesion types, as determined by cervicography.Design: a cross sectional study Setting: Gynecologic Cancer Prevention Unit of the University Teaching Hospital, Zambia.Population: Women referred to the study site for histologic evaluation of cryotherapy-ineligible lesions of the cervix were included in the study.Individual acetowhite lesion types which do not meet criteria for cryotherapy include those that (1)cover more than 75% of the transformation zone, (2) disappear into the endocervical canal, (3) contain abnormal vasculature (mosaicism, punctuations, or atypical blood vessels), and (4) are thick.Main outcome measures: Histologic diagnosis of high grade cervical intraepithelial neoplasia (CIN 2+) for each cryotherapy-ineligible acetowhite lesion type of the cervix.Results: A total of 130 women were enrolled into the study. Women with lesions occupying greater than 75% of the transformation zone had five fold greater odds of CIN 2+ than women with other lesions, OR 4.5 (95% CI 2.19.9), p < 0.001. Women with thick acetowhite lesions were less likely to have CIN 2+, OR 1.1 (95% CI 0.4 3.0), p=0.84. Women with lesions disappearing into the endocervix beyond complete visualization were far less likely to have CIN 2+, OR 0.1 (95% CI 0.040.45), p< 0.001. No association was detected between CIN 2+ and lesions with abnormal vessels. After multivariable adjustment, there remained a significant association between lesions covering greater than 75% of the transformation zone and CIN 2+, OR 2.2 (95% CI 1.43.4). However, other individual cryotherapy-ineligible acetowhite lesion types were no longer associated with CIN 2+. Conclusions: Cryotherapy-ineligible acetowhite lesions occupying greater than 75% of the transformation zone diagnosed on cervicography are associated with histopathologic outcome of high grade cervical intraepithelial neoplasia."],"dc:identifier.uri":["http://dspace.unza.zm/handle/123456789/1082"],"dc:language.iso":["en"],"dc:subject":["Cervical Vertebrae(women)--Radiography","Gynecology","Women--medical examinations"],"dc:title":["A Study of Histopathologic Outcomes of Women With Cryotherapy-Ineligible lesions on Cervicography"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T22:06:13Z"}