{"id":{"repo_id":"york","oai_identifier":"oai:yorkspace.library.yorku.ca:10315/43386"},"canonical_url":"https://search.dev.ndltd.org/etd/york/oai:yorkspace.library.yorku.ca:10315/43386","repository":{"repo_id":"york","name":"York University","base_url":"https://yorkspace.library.yorku.ca/oai/request"},"display":{"title":"Cellular Stress and Effects on Mitochondrial DNA: An Assessment of Stress Reduction & Protective Effects","abstract":"Introduction: Psychological stress results in energy demands and changes in the mitochondria that produce 90% of bodily energy as adenosine triphosphate (ATP). Cell-free mitochondrial DNA (cf-mtDNA) is released into the bloodstream under stress which was induced with the International Affective Picture System (IAPS). We hypothesized that participants exposed to mindfulness meditation (MM) instruction would demonstrate lesser increases in cf-mtDNA levels and negative mood states compared to controls. Methods: Thirty-five females (18-30 years) were randomized to an experimental group (MM) or a control group (educational podcast). Both groups viewed IAPS images, completed questionnaires and two blood draws. Results: A paired samples t-test revealed no significant differences in cf-mtDNA levels from pre- to post- IAPS stress exposure between groups. Conclusion: This randomized controlled trial is the first study to explore the potentially protective effects of MM on cf-mtDNA levels and mood after an acute lab stressor. No statistically significant results were found.","abstract_html":"Introduction: Psychological stress results in energy demands and changes in the mitochondria that produce 90% of bodily energy as adenosine triphosphate (ATP). Cell-free mitochondrial DNA (cf-mtDNA) is released into the bloodstream under stress which was induced with the International Affective Picture System (IAPS). We hypothesized that participants exposed to mindfulness meditation (MM) instruction would demonstrate lesser increases in cf-mtDNA levels and negative mood states compared to controls. Methods: Thirty-five females (18-30 years) were randomized to an experimental group (MM) or a control group (educational podcast). Both groups viewed IAPS images, completed questionnaires and two blood draws. Results: A paired samples t-test revealed no significant differences in cf-mtDNA levels from pre- to post- IAPS stress exposure between groups. Conclusion: This randomized controlled trial is the first study to explore the potentially protective effects of MM on cf-mtDNA levels and mood after an acute lab stressor. No statistically significant results were found.","abstract_has_math":false,"creators":["Tiwana, Jasmin Kaur"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Ritvo, Paul G."],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-11-11","date_published":"2025-11-11","updated_at":"2026-07-24T06:33:46Z","subjects":["Health sciences","Kinesiology"],"languages":["en"],"rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10315/43386","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Ritvo, Paul G."]},{"key":"dc:creator","label":"Author","values":["Tiwana, Jasmin Kaur"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-11-11T20:15:05Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-11-11T20:15:05Z"]},{"key":"dc:date.issued","label":"Date","values":["2025-11-11"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health sciences","Kinesiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10315/43386"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Introduction: Psychological stress results in energy demands and changes in the mitochondria that produce 90% of bodily energy as adenosine triphosphate (ATP). Cell-free mitochondrial DNA (cf-mtDNA) is released into the bloodstream under stress which was induced with the International Affective Picture System (IAPS). We hypothesized that participants exposed to mindfulness meditation (MM) instruction would demonstrate lesser increases in cf-mtDNA levels and negative mood states compared to controls. Methods: Thirty-five females (18-30 years) were randomized to an experimental group (MM) or a control group (educational podcast). Both groups viewed IAPS images, completed questionnaires and two blood draws. Results: A paired samples t-test revealed no significant differences in cf-mtDNA levels from pre- to post- IAPS stress exposure between groups. Conclusion: This randomized controlled trial is the first study to explore the potentially protective effects of MM on cf-mtDNA levels and mood after an acute lab stressor. No statistically significant results were found."]},{"key":"dc:title","label":"Title","values":["Cellular Stress and Effects on Mitochondrial DNA: An Assessment of Stress Reduction & Protective Effects"]}]}],"canonical_facts":{"dc:contributor.advisor":["Ritvo, Paul G."],"dc:creator":["Tiwana, Jasmin Kaur"],"dc:date.accessioned":["2025-11-11T20:15:05Z"],"dc:date.available":["2025-11-11T20:15:05Z"],"dc:date.issued":["2025-11-11"],"dc:description.abstract":["Introduction: Psychological stress results in energy demands and changes in the mitochondria that produce 90% of bodily energy as adenosine triphosphate (ATP). Cell-free mitochondrial DNA (cf-mtDNA) is released into the bloodstream under stress which was induced with the International Affective Picture System (IAPS). We hypothesized that participants exposed to mindfulness meditation (MM) instruction would demonstrate lesser increases in cf-mtDNA levels and negative mood states compared to controls. Methods: Thirty-five females (18-30 years) were randomized to an experimental group (MM) or a control group (educational podcast). Both groups viewed IAPS images, completed questionnaires and two blood draws. Results: A paired samples t-test revealed no significant differences in cf-mtDNA levels from pre- to post- IAPS stress exposure between groups. Conclusion: This randomized controlled trial is the first study to explore the potentially protective effects of MM on cf-mtDNA levels and mood after an acute lab stressor. No statistically significant results were found."],"dc:identifier.uri":["https://hdl.handle.net/10315/43386"],"dc:language":["en"],"dc:rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"dc:subject":["Health sciences","Kinesiology"],"dc:title":["Cellular Stress and Effects on Mitochondrial DNA: An Assessment of Stress Reduction & Protective Effects"],"dc:type":["Electronic Thesis or Dissertation"]},"updated_at":"2026-07-24T06:33:46Z"}