{"id":{"repo_id":"york","oai_identifier":"oai:yorkspace.library.yorku.ca:10315/42845"},"canonical_url":"https://search.dev.ndltd.org/etd/york/oai:yorkspace.library.yorku.ca:10315/42845","repository":{"repo_id":"york","name":"York University","base_url":"https://yorkspace.library.yorku.ca/oai/request"},"display":{"title":"Sex Differences In Endothelial FoxO1 Response To Nutrient And Oxidative Stress","abstract":"Endothelial cells (ECs) are vital for vascular homeostasis, regulating blood flow, nutrient exchange, and immune responses. EC dysfunction contributes to diseases such as type 2 diabetes, atherosclerosis, and hypertension, with sex-specific differences in disease progression. Our lab previously observed sex differences in the response of adipose tissue ECs (ATECs) to high-fat diet-induced metabolic and oxidative stress, with females showing more favorable outcomes. Female ECs express higher Forkhead Box O1 (FoxO1) levels than males, suggesting sex-specific FoxO1 regulation. To explore this, male and female ECs were exposed to metabolic and oxidative stress, and FoxO1 subcellular localization and post-translational modifications were assessed. Male ECs showed increased FoxO1 phosphorylation and cytoplasmic localization, while females retained FoxO1 in the nucleus, supporting enhanced transcriptional potential. These findings highlight sex-dependent FoxO1 regulation, offering insights into molecular mechanisms driving sex differences in vascular health.","abstract_html":"Endothelial cells (ECs) are vital for vascular homeostasis, regulating blood flow, nutrient exchange, and immune responses. EC dysfunction contributes to diseases such as type 2 diabetes, atherosclerosis, and hypertension, with sex-specific differences in disease progression. Our lab previously observed sex differences in the response of adipose tissue ECs (ATECs) to high-fat diet-induced metabolic and oxidative stress, with females showing more favorable outcomes. Female ECs express higher Forkhead Box O1 (FoxO1) levels than males, suggesting sex-specific FoxO1 regulation. To explore this, male and female ECs were exposed to metabolic and oxidative stress, and FoxO1 subcellular localization and post-translational modifications were assessed. Male ECs showed increased FoxO1 phosphorylation and cytoplasmic localization, while females retained FoxO1 in the nucleus, supporting enhanced transcriptional potential. These findings highlight sex-dependent FoxO1 regulation, offering insights into molecular mechanisms driving sex differences in vascular health.","abstract_has_math":false,"creators":["Nahal, Manvir Singh"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Tara Haas"],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-04-10","date_published":"2025-04-10","updated_at":"2026-07-24T06:33:58Z","subjects":[],"languages":["en"],"rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10315/42845","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Tara Haas"]},{"key":"dc:creator","label":"Author","values":["Nahal, Manvir Singh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-04-10T10:54:01Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-04-10T10:54:01Z"]},{"key":"dc:date.issued","label":"Date","values":["2025-04-10"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10315/42845"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Endothelial cells (ECs) are vital for vascular homeostasis, regulating blood flow, nutrient exchange, and immune responses. EC dysfunction contributes to diseases such as type 2 diabetes, atherosclerosis, and hypertension, with sex-specific differences in disease progression. Our lab previously observed sex differences in the response of adipose tissue ECs (ATECs) to high-fat diet-induced metabolic and oxidative stress, with females showing more favorable outcomes. Female ECs express higher Forkhead Box O1 (FoxO1) levels than males, suggesting sex-specific FoxO1 regulation. To explore this, male and female ECs were exposed to metabolic and oxidative stress, and FoxO1 subcellular localization and post-translational modifications were assessed. Male ECs showed increased FoxO1 phosphorylation and cytoplasmic localization, while females retained FoxO1 in the nucleus, supporting enhanced transcriptional potential. These findings highlight sex-dependent FoxO1 regulation, offering insights into molecular mechanisms driving sex differences in vascular health."]},{"key":"dc:title","label":"Title","values":["Sex Differences In Endothelial FoxO1 Response To Nutrient And Oxidative Stress"]}]}],"canonical_facts":{"dc:contributor.advisor":["Tara Haas"],"dc:creator":["Nahal, Manvir Singh"],"dc:date.accessioned":["2025-04-10T10:54:01Z"],"dc:date.available":["2025-04-10T10:54:01Z"],"dc:date.issued":["2025-04-10"],"dc:description.abstract":["Endothelial cells (ECs) are vital for vascular homeostasis, regulating blood flow, nutrient exchange, and immune responses. EC dysfunction contributes to diseases such as type 2 diabetes, atherosclerosis, and hypertension, with sex-specific differences in disease progression. Our lab previously observed sex differences in the response of adipose tissue ECs (ATECs) to high-fat diet-induced metabolic and oxidative stress, with females showing more favorable outcomes. Female ECs express higher Forkhead Box O1 (FoxO1) levels than males, suggesting sex-specific FoxO1 regulation. To explore this, male and female ECs were exposed to metabolic and oxidative stress, and FoxO1 subcellular localization and post-translational modifications were assessed. Male ECs showed increased FoxO1 phosphorylation and cytoplasmic localization, while females retained FoxO1 in the nucleus, supporting enhanced transcriptional potential. These findings highlight sex-dependent FoxO1 regulation, offering insights into molecular mechanisms driving sex differences in vascular health."],"dc:identifier.uri":["https://hdl.handle.net/10315/42845"],"dc:language":["en"],"dc:rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"dc:title":["Sex Differences In Endothelial FoxO1 Response To Nutrient And Oxidative Stress"],"dc:type":["Electronic Thesis or Dissertation"]},"updated_at":"2026-07-24T06:33:58Z"}