{"id":{"repo_id":"york","oai_identifier":"oai:yorkspace.library.yorku.ca:10315/37470"},"canonical_url":"https://search.dev.ndltd.org/etd/york/oai:yorkspace.library.yorku.ca:10315/37470","repository":{"repo_id":"york","name":"York University","base_url":"https://yorkspace.library.yorku.ca/oai/request"},"display":{"title":"Carbohydrate Supplementation During Prolonged Aerobic Exercise for People Living with Type 1 Diabetes on Insulin Pump Therapy: The ExCarbs Study","abstract":"Moderate intensity exercise increases hypoglycemia risk in individuals with type 1 diabetes. This thesis assessed carbohydrate and insulin strategies during 120-min fasted exercise (~45% VO2peak) in fifteen individuals with type 1 diabetes. The strategies performed in randomized crossover design included: 1) carbohydrates of 0.3 g/kg/hr; 2) 50% basal rate reduction 90-min pre-exercise; and 3) carbohydrates of 0.3 g/kg/hr and 50% basal rate reduction at exercise start. In arms 1, 2, and 3 the change in blood glucose was -2.7 3.4 mmol/L, -1.9 2.5 mmol/L, and 0.3 2.6 mmol/L, respectively. Arm 2 had a lower RER (0.79 0.04), increased ketones (0.4 0.3 mmol/L), increased fat oxidation (0.51 0.2 g/min), and increased glucagon (30.9 22.3 pg/mL) at exercise end, compared to arm 1 (all P < 0.05). All strategies had minimal hypoglycemia throughout exercise, with arm 2 having increased fat oxidation and improved counter-regulatory function.","abstract_html":"Moderate intensity exercise increases hypoglycemia risk in individuals with type 1 diabetes. This thesis assessed carbohydrate and insulin strategies during 120-min fasted exercise (~45% VO2peak) in fifteen individuals with type 1 diabetes. The strategies performed in randomized crossover design included: 1) carbohydrates of 0.3 g/kg/hr; 2) 50% basal rate reduction 90-min pre-exercise; and 3) carbohydrates of 0.3 g/kg/hr and 50% basal rate reduction at exercise start. In arms 1, 2, and 3 the change in blood glucose was -2.7 3.4 mmol/L, -1.9 2.5 mmol/L, and 0.3 2.6 mmol/L, respectively. Arm 2 had a lower RER (0.79 0.04), increased ketones (0.4 0.3 mmol/L), increased fat oxidation (0.51 0.2 g/min), and increased glucagon (30.9 22.3 pg/mL) at exercise end, compared to arm 1 (all P &lt; 0.05). All strategies had minimal hypoglycemia throughout exercise, with arm 2 having increased fat oxidation and improved counter-regulatory function.","abstract_has_math":false,"creators":["McGaugh, Sarah Marie"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Riddell, Michael C."],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-05-11","date_published":"2020-05-11","updated_at":"2026-07-24T06:33:40Z","subjects":["Physiology"],"languages":["en"],"rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10315/37470","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Riddell, Michael C."]},{"key":"dc:creator","label":"Author","values":["McGaugh, Sarah Marie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-05-11T12:54:21Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-05-11T12:54:21Z"]},{"key":"dc:date.issued","label":"Date","values":["2020-05-11"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Physiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10315/37470"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Moderate intensity exercise increases hypoglycemia risk in individuals with type 1 diabetes. This thesis assessed carbohydrate and insulin strategies during 120-min fasted exercise (~45% VO2peak) in fifteen individuals with type 1 diabetes. The strategies performed in randomized crossover design included: 1) carbohydrates of 0.3 g/kg/hr; 2) 50% basal rate reduction 90-min pre-exercise; and 3) carbohydrates of 0.3 g/kg/hr and 50% basal rate reduction at exercise start. In arms 1, 2, and 3 the change in blood glucose was -2.7 3.4 mmol/L, -1.9 2.5 mmol/L, and 0.3 2.6 mmol/L, respectively. Arm 2 had a lower RER (0.79 0.04), increased ketones (0.4 0.3 mmol/L), increased fat oxidation (0.51 0.2 g/min), and increased glucagon (30.9 22.3 pg/mL) at exercise end, compared to arm 1 (all P < 0.05). All strategies had minimal hypoglycemia throughout exercise, with arm 2 having increased fat oxidation and improved counter-regulatory function."]},{"key":"dc:title","label":"Title","values":["Carbohydrate Supplementation During Prolonged Aerobic Exercise for People Living with Type 1 Diabetes on Insulin Pump Therapy: The ExCarbs Study"]}]}],"canonical_facts":{"dc:contributor.advisor":["Riddell, Michael C."],"dc:creator":["McGaugh, Sarah Marie"],"dc:date.accessioned":["2020-05-11T12:54:21Z"],"dc:date.available":["2020-05-11T12:54:21Z"],"dc:date.issued":["2020-05-11"],"dc:description.abstract":["Moderate intensity exercise increases hypoglycemia risk in individuals with type 1 diabetes. This thesis assessed carbohydrate and insulin strategies during 120-min fasted exercise (~45% VO2peak) in fifteen individuals with type 1 diabetes. The strategies performed in randomized crossover design included: 1) carbohydrates of 0.3 g/kg/hr; 2) 50% basal rate reduction 90-min pre-exercise; and 3) carbohydrates of 0.3 g/kg/hr and 50% basal rate reduction at exercise start. In arms 1, 2, and 3 the change in blood glucose was -2.7 3.4 mmol/L, -1.9 2.5 mmol/L, and 0.3 2.6 mmol/L, respectively. Arm 2 had a lower RER (0.79 0.04), increased ketones (0.4 0.3 mmol/L), increased fat oxidation (0.51 0.2 g/min), and increased glucagon (30.9 22.3 pg/mL) at exercise end, compared to arm 1 (all P < 0.05). All strategies had minimal hypoglycemia throughout exercise, with arm 2 having increased fat oxidation and improved counter-regulatory function."],"dc:identifier.uri":["https://hdl.handle.net/10315/37470"],"dc:language":["en"],"dc:rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"dc:subject":["Physiology"],"dc:title":["Carbohydrate Supplementation During Prolonged Aerobic Exercise for People Living with Type 1 Diabetes on Insulin Pump Therapy: The ExCarbs Study"],"dc:type":["Electronic Thesis or Dissertation"]},"updated_at":"2026-07-24T06:33:40Z"}