{"id":{"repo_id":"york","oai_identifier":"oai:yorkspace.library.yorku.ca:10315/37437"},"canonical_url":"https://search.dev.ndltd.org/etd/york/oai:yorkspace.library.yorku.ca:10315/37437","repository":{"repo_id":"york","name":"York University","base_url":"https://yorkspace.library.yorku.ca/oai/request"},"display":{"title":"Oxytocin and Genetic Links with Eating Behaviours and Relevant Endophenotypes","abstract":"Oxytocin (OXT) is an ancestral neuropeptide hormone essential in the regulation of human behaviours vital for sustaining life such as food intake and reproduction. Importantly, these behaviours have strong associations with the brains reward circuitry. To date, there has been little OXT-genetic research in the field of eating behaviors. However, a recent study by Davis et al. (2017) identified several single nucleotide polymorphisms (SNPs) on the OXT receptor gene (OXTR), associated with overeating and relevant behaviours. The present study expanded on this work by analyzing SNPs of the LNPEP, CD38, and OXTG genes. Additionally, sex differences were also examined. A pre-existing data set consisting of 460 healthy volunteers was used in the study. A series of two-way MANOVAs were employed and results indicated nonsignificant main effects for genotype on all 12 SNPs. However, multivariate tests for sex were significant in each analysis. Possible explanations for the current findings are discussed.","abstract_html":"Oxytocin (OXT) is an ancestral neuropeptide hormone essential in the regulation of human behaviours vital for sustaining life such as food intake and reproduction. Importantly, these behaviours have strong associations with the brains reward circuitry. To date, there has been little OXT-genetic research in the field of eating behaviors. However, a recent study by Davis et al. (2017) identified several single nucleotide polymorphisms (SNPs) on the OXT receptor gene (OXTR), associated with overeating and relevant behaviours. The present study expanded on this work by analyzing SNPs of the LNPEP, CD38, and OXTG genes. Additionally, sex differences were also examined. A pre-existing data set consisting of 460 healthy volunteers was used in the study. A series of two-way MANOVAs were employed and results indicated nonsignificant main effects for genotype on all 12 SNPs. However, multivariate tests for sex were significant in each analysis. Possible explanations for the current findings are discussed.","abstract_has_math":false,"creators":["Adams, Nicole Ruth"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Davis, Caroline A."],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-05-11","date_published":"2020-05-11","updated_at":"2026-07-24T06:33:43Z","subjects":["Psychology"],"languages":["en"],"rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10315/37437","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Davis, Caroline A."]},{"key":"dc:creator","label":"Author","values":["Adams, Nicole Ruth"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-05-11T12:49:54Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-05-11T12:49:54Z"]},{"key":"dc:date.issued","label":"Date","values":["2020-05-11"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Psychology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10315/37437"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Oxytocin (OXT) is an ancestral neuropeptide hormone essential in the regulation of human behaviours vital for sustaining life such as food intake and reproduction. Importantly, these behaviours have strong associations with the brains reward circuitry. To date, there has been little OXT-genetic research in the field of eating behaviors. However, a recent study by Davis et al. (2017) identified several single nucleotide polymorphisms (SNPs) on the OXT receptor gene (OXTR), associated with overeating and relevant behaviours. The present study expanded on this work by analyzing SNPs of the LNPEP, CD38, and OXTG genes. Additionally, sex differences were also examined. A pre-existing data set consisting of 460 healthy volunteers was used in the study. A series of two-way MANOVAs were employed and results indicated nonsignificant main effects for genotype on all 12 SNPs. However, multivariate tests for sex were significant in each analysis. Possible explanations for the current findings are discussed."]},{"key":"dc:title","label":"Title","values":["Oxytocin and Genetic Links with Eating Behaviours and Relevant Endophenotypes"]}]}],"canonical_facts":{"dc:contributor.advisor":["Davis, Caroline A."],"dc:creator":["Adams, Nicole Ruth"],"dc:date.accessioned":["2020-05-11T12:49:54Z"],"dc:date.available":["2020-05-11T12:49:54Z"],"dc:date.issued":["2020-05-11"],"dc:description.abstract":["Oxytocin (OXT) is an ancestral neuropeptide hormone essential in the regulation of human behaviours vital for sustaining life such as food intake and reproduction. Importantly, these behaviours have strong associations with the brains reward circuitry. To date, there has been little OXT-genetic research in the field of eating behaviors. However, a recent study by Davis et al. (2017) identified several single nucleotide polymorphisms (SNPs) on the OXT receptor gene (OXTR), associated with overeating and relevant behaviours. The present study expanded on this work by analyzing SNPs of the LNPEP, CD38, and OXTG genes. Additionally, sex differences were also examined. A pre-existing data set consisting of 460 healthy volunteers was used in the study. A series of two-way MANOVAs were employed and results indicated nonsignificant main effects for genotype on all 12 SNPs. However, multivariate tests for sex were significant in each analysis. Possible explanations for the current findings are discussed."],"dc:identifier.uri":["https://hdl.handle.net/10315/37437"],"dc:language":["en"],"dc:rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"dc:subject":["Psychology"],"dc:title":["Oxytocin and Genetic Links with Eating Behaviours and Relevant Endophenotypes"],"dc:type":["Electronic Thesis or Dissertation"]},"updated_at":"2026-07-24T06:33:43Z"}