{"id":{"repo_id":"york","oai_identifier":"oai:yorkspace.library.yorku.ca:10315/35905"},"canonical_url":"https://search.dev.ndltd.org/etd/york/oai:yorkspace.library.yorku.ca:10315/35905","repository":{"repo_id":"york","name":"York University","base_url":"https://yorkspace.library.yorku.ca/oai/request"},"display":{"title":"Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging","abstract":"The prevalence of fetal alcohol spectrum disorder (FASD) is increasing exponentially due to the in-cognizant consumption of alcohol during early pregnancy. This research primarily focuses on monitoring the variation of phospholipid distribution in various regions of the brain using DESI-MS imaging. FASD mouse models were used in this study in which alcohol was administered to the pregnant mice during first trimester and 30 day old offsprings were chosen for the analysis. Principal component analysis was performed on six samples that illustrated enhanced level of PC(16:0/16:0), PC (16:0/18:1) throughout the brain; while the level of PE(P-16:0/22:6), PS(18:0/18:1), PS(18:0/20:0), PS(18:0/22:6), PI(18:0/20:4) and ST(24:1) increased specifically in the white matter of the brain in response to alcohol consumption. Conversely, alcohol reduced the level of PC(16:0/18:1), PE(P-18:0/22:6) and PC(18:0/18:1) exclusively in white matter of the brain. The changes noted in various phospholipids lay strong foundation for understanding alcohol mediated biochemistry in fetal brain development.","abstract_html":"The prevalence of fetal alcohol spectrum disorder (FASD) is increasing exponentially due to the in-cognizant consumption of alcohol during early pregnancy. This research primarily focuses on monitoring the variation of phospholipid distribution in various regions of the brain using DESI-MS imaging. FASD mouse models were used in this study in which alcohol was administered to the pregnant mice during first trimester and 30 day old offsprings were chosen for the analysis. Principal component analysis was performed on six samples that illustrated enhanced level of PC(16:0/16:0), PC (16:0/18:1) throughout the brain; while the level of PE(P-16:0/22:6), PS(18:0/18:1), PS(18:0/20:0), PS(18:0/22:6), PI(18:0/20:4) and ST(24:1) increased specifically in the white matter of the brain in response to alcohol consumption. Conversely, alcohol reduced the level of PC(16:0/18:1), PE(P-18:0/22:6) and PC(18:0/18:1) exclusively in white matter of the brain. The changes noted in various phospholipids lay strong foundation for understanding alcohol mediated biochemistry in fetal brain development.","abstract_has_math":false,"creators":["Bagga, Aafreen Kaur"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Ifa, Demian R."],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-03-05","date_published":"2019-03-05","updated_at":"2026-07-24T06:33:58Z","subjects":["Health sciences"],"languages":["en"],"rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10315/35905","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Ifa, Demian R."]},{"key":"dc:creator","label":"Author","values":["Bagga, Aafreen Kaur"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2019-03-05T14:58:44Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2019-03-05T14:58:44Z"]},{"key":"dc:date.issued","label":"Date","values":["2019-03-05"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10315/35905"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The prevalence of fetal alcohol spectrum disorder (FASD) is increasing exponentially due to the in-cognizant consumption of alcohol during early pregnancy. This research primarily focuses on monitoring the variation of phospholipid distribution in various regions of the brain using DESI-MS imaging. FASD mouse models were used in this study in which alcohol was administered to the pregnant mice during first trimester and 30 day old offsprings were chosen for the analysis. Principal component analysis was performed on six samples that illustrated enhanced level of PC(16:0/16:0), PC (16:0/18:1) throughout the brain; while the level of PE(P-16:0/22:6), PS(18:0/18:1), PS(18:0/20:0), PS(18:0/22:6), PI(18:0/20:4) and ST(24:1) increased specifically in the white matter of the brain in response to alcohol consumption. Conversely, alcohol reduced the level of PC(16:0/18:1), PE(P-18:0/22:6) and PC(18:0/18:1) exclusively in white matter of the brain. The changes noted in various phospholipids lay strong foundation for understanding alcohol mediated biochemistry in fetal brain development."]},{"key":"dc:title","label":"Title","values":["Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging"]}]}],"canonical_facts":{"dc:contributor.advisor":["Ifa, Demian R."],"dc:creator":["Bagga, Aafreen Kaur"],"dc:date.accessioned":["2019-03-05T14:58:44Z"],"dc:date.available":["2019-03-05T14:58:44Z"],"dc:date.issued":["2019-03-05"],"dc:description.abstract":["The prevalence of fetal alcohol spectrum disorder (FASD) is increasing exponentially due to the in-cognizant consumption of alcohol during early pregnancy. This research primarily focuses on monitoring the variation of phospholipid distribution in various regions of the brain using DESI-MS imaging. FASD mouse models were used in this study in which alcohol was administered to the pregnant mice during first trimester and 30 day old offsprings were chosen for the analysis. Principal component analysis was performed on six samples that illustrated enhanced level of PC(16:0/16:0), PC (16:0/18:1) throughout the brain; while the level of PE(P-16:0/22:6), PS(18:0/18:1), PS(18:0/20:0), PS(18:0/22:6), PI(18:0/20:4) and ST(24:1) increased specifically in the white matter of the brain in response to alcohol consumption. Conversely, alcohol reduced the level of PC(16:0/18:1), PE(P-18:0/22:6) and PC(18:0/18:1) exclusively in white matter of the brain. The changes noted in various phospholipids lay strong foundation for understanding alcohol mediated biochemistry in fetal brain development."],"dc:identifier.uri":["http://hdl.handle.net/10315/35905"],"dc:language.iso":["en"],"dc:rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"dc:subject":["Health sciences"],"dc:title":["Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging"],"dc:type":["Electronic Thesis or Dissertation"]},"updated_at":"2026-07-24T06:33:58Z"}